呼吸训练联合沙美特罗替卡松和噻托溴铵在老年COPD患者中的应用研究

Clinical efficiency of respiratory training combined with salmeterol fluticasone and tiotropium in elderly patients with COPD

目的探讨呼吸训练配合沙美特罗替卡松及噻托溴铵治疗老年慢性阻塞性肺疾病(COPD)的疗效及其对肺功能和血气分析指标的影响。方法将84例老年COPD患者按照随机数字表法分为对照组和观察组,每组各42例;对照组患者予以噻托溴铵和沙美特罗替卡松吸入治疗,观察组则在此基础之上同时配合呼吸训练。结果治疗后,两组患者临床症状和生活质量评分均治疗前下降,1秒用力呼气容积(FEV1)、FEV1占预计值百分比、FEV1占用力肺活量比值,以及动脉血氧分压和血二氧化碳分压均较治疗前显著改善(P<0.05)。但与对照组相比,观察组上述各项指标的改善效果更为明显,组间比较差异均有统计学意义(P<0.05)。结论呼吸训练配合沙美特罗替卡松和噻托溴铵对老年COPD患者的临床疗效优于单独药物治疗,并可更好地改善机体肺功能和血气分析指标。

Objective To explore the clinical efficiency of respiratory training combined with salmeterol fluti-casone and tiotropium in elderly patients with chronic obstructive pulmonary diseases （COPD） and its effect on pul-monary function and blood gas indicators .Methods According to the random number table ,a total of 84 elderly pa-tients with COPD were divided into control group and observation group ,with 42 cases for each group .The control group was given inhaled tiotropium and salmeterol fluticasone treatment ,and the observation group was given both drug therapy and respiratory training .Results After treatment ,clinical symptoms and quality of life scores were de-clined ,and the forced expiratory volume in one second （FEV1） ,ratio of FEV1 to anticipated value ,ratio of FEV1 to forced vital capacity ,arterial partial pressure of oxygen and arterial partial pressure of oxygen carbon dioxide signifi-cantly improved ,compared with those before treatment （P＆lt;0 .05） .However ,compared with control group ,the im-provement of these indicators in observation group was more obvious （P＆lt;0 .05） .Conclusion The clinical efficacy of respiratory training combined with salmeterol and tiotropium in elderly patients with COPD could be superior to med-ical therapy alone ,which could improve the lung function and blood gas indicators .