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超声对肝细胞肝癌诊断价值及其与肿瘤血管生成相关性分析 被引量:3

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摘要 目的探讨肝细胞肝癌的诊断价值及其与肿瘤血管生成的相关性。方法选取内蒙古医科大学附属医院及内蒙古自治区医院2009年4月至2012年12月收治的82例肝细胞肝癌患者,于术前对所有患者进行超声造影检查,通过时间———强度曲线获得肿瘤组织及癌旁组织的峰值强度(PI),在手术后将术中切除的标本进行病理及免疫组织化学染色,测量肿瘤及癌旁组织的微血管密度(MVD)。比较肿瘤与癌旁组织的PI与MVD,并作相关性分析。结果肿瘤病灶的PI与MVD为(40.39±10.74)dB、(53.52±18.16),均明显高于癌旁组织的(19.64±5.87)dB、(23.05±8.85),差异有统计学意义(P<0.01);肿瘤病灶与癌旁组织PI值均与MVD值呈正相关(r=0.759,P=0.021)。结论超声检查能够较为客观详细地对肝细胞肝癌患者的病灶性质作出评价,且超声造影定量灌注参数与肿瘤组织中的MVD相关性较高,该项指标可为临床进一步诊断及治疗提供有力依据。
作者 苏岩
出处 《检验医学与临床》 CAS 2014年第6期784-785,共2页 Laboratory Medicine and Clinic
基金 内蒙古自然科学基金(2011MS112)
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  • 1Wei Lin,Jinyan Zhao,Zhiyun Cao. Livistona chinensis seeds inhibit hepatocellular carcinoma angiogenesis in vivo via suppression of the Notch pathway[J]. Oncology Reports ,2014,31(4):1723-1728.
  • 2Vande Veire S,Stalmans I, Heindryckx F. Further pharmacological and genetic evidence for the efficacy of PlGF in- hibition in cancer and eye disease[J]. Cell,2010,141(1):178-190.
  • 3Ping Zhan,Qian Qian, Li Yu ke. Prognostic significance of vascular endothelial growth factor expression in hepatocellular carcinoma tissue: A meta-analysis[J], Hepatobiliary Surgery and Nutrition,2013,2(3);148-155.
  • 4Raskopf E,Vogt A Standop. Inhibition of neuropilin-1 by RNA - interference and its angiostatic potential in the treatment of hepatocellular carcinoma[J]. Zeitschrift Fur Gastroenterologie,2010,48(1):21-27.
  • 5Wenbo Meng,Xun Li, Zhongtian Bai. Silencing alpha-fe-toprotein inhibits VEGF and MMP -2/9 production in human hepatocellular carcinoma cell[J]. Plo S One,2014,9(2):90660.
  • 6Feng LL,Liu BX,Zhong JY,et al. Effect of grape pro-cyanidins on tumor angiogenesis in liver cancer xenograft models[J]. Asian Pacific Journal of Cancer Prevention : APJCP,2014,15(2):737-741.
  • 7Hirayuki EnomotosHideji Nakamura,Weidong Liu. Down-regulation of HDGF inhibits the growth of hepatocellular carcinoma cells in vitro and in vivo[J]. Anticancer Research ,2015,35(12):6475-6479.
  • 8Jun Muto,Ken Shirabe, Keishi Sugimachi. Review of angiogenesis in hepatocellular carcinoma[J]. Hepatology Research :The Official Journal of The japan Society of Hep-atology,2015,45(1):l-9.
  • 9Yang XM,Zhu HP,Hu ZX. Dendritic cells transduced with TEM8 recombinant adenovirus prevents hepatocellular carcinoma angiogenesis and inhibits cells growth[J]. Vaccine,2010,28(43):7130-7135.
  • 10Lu LC,Shao YY,Chan SY. Clinical characteristics of advanced hepatocellular carcinoma patients with prolonged survival in the era of anti-angiogenic targeted-therapy[J]. Anticancer Research,2014,34(2):1047-1052.

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