替吉奥胶囊联合奥沙利铂治疗老年晚期食管癌疗效观察

Efficiency of combination chemotherapy with S-1 and Oxaliplantin in the treatment of old advanced esophageal cancer patients

目的观察替吉奥胶囊联合奥沙利铂治疗老年晚期食管癌的临床疗效和不良反应。方法 63例晚期食管癌患者,年龄均>65岁,采用替吉奥胶囊联合奥沙利铂方案治疗,21 d为一周期,治疗2个周期后评价疗效及不良反应。结果 63例患者中CR 8例,PR 23例,SD 14例,PD 18例,有效率RR为49.2%,中位生存时间10.4个月。毒副反应主要为感觉神经毒性、消化道反应和血液学毒性。结论替吉奥胶囊联合奥沙利铂治疗老年晚期食管癌疗效较好,不良反应轻,患者耐受性好,值得临床推广应用。

Objective To observe the efficacy and side effects of S-1 and oxaliplantin in the treatment of old advanced esophageal cancer patients. Methods 63 cases of advanced esophageal cancer, all were older than 65, treated with S-1 and oxaliplantin, the cycle was repeated every 21 days, after two consecutive treatment, the short term efficacy and adverse effects was observed. Results Among the 63 patients, 8 paients were CR, 23 patients PR, 14 SD, 18 PD, the overall response rate was 49. 2%, the middle survival time was 10.4 months. Major side-effects were neurosensory toxicity, gastrointestinal disturbance, and hematological toxicities. Conclusion S-1 and Oxaliplantin is effective for the old advanced esophageal cancer patients, and the toxicity and side-effects are tolerable.