美托洛尔缓释片联合替米沙坦治疗冠心病并高血压临床研究

Clinical research on metoprolol succinate combined with telmisartan for patients with hypertension accompanied by coronary heart disease

目的：探讨美托洛尔缓释片联合替米沙坦治疗冠心病并高血压的临床效果。方法以本院2012年10月1日~2012年10月30日收治的80例冠心病并高血压患者为研究对象，随机分为两组，各40例。对照组单独服用美托洛尔缓释片进行治疗，实验组则在服用美托洛尔缓释片的基础之上同时联合使用替米沙坦，所有患者均接受冠心病常规治疗。四周后，对两组的治疗效果，包括降压水平以及治疗后心绞痛发作次数，利用SPSS软件对统计结果进行统计分析。结果对照组患者和实验组患者经治疗后SBP、DBP均显著下降，且实验组与对照组比较，其血压降低水平更高；同时，实验组和对照组治疗有效患者中，心绞痛发作次数明显降低。结论美托洛尔缓释片联合替米沙坦的治疗方法在冠心病并高血压的治疗效果优于单独使用美托洛尔缓释片，是一种更有效的治疗方法，值得在临床上推广应用。

Objective To study the effect of metoprolol succinate combined with telmisartan on patients with hypertension accompanied by coronary heart disease. Methods 80 patients in Zhumadian Center Hospital during October1 to 30 2012 with hypertension and coronary heart disease were randomized in two groups, experimental group （40 Patients） and the control group（40 Patients）, the experimental group received metoprolol succinate and telmisartan and the control group received only metoprolol succinate. All the patients recept routine therapy. Both groups were followed up for 4 weeks. Blood pressure and Angina were evaluated at the end of follow up. Results SBP/DBP were decreased markedly in two groups and a lower blood pressure was found in the Experimental group, meanwhile, the Angina frequency was reduced. Conclusion The total effective rate of combined treatment group is significantly higher than the monotherapy group after four weeks’treatment in patients with coronary heart disease and no severe adverse effect appeares.