乳腺癌患者血清中MMP-2、MMP-9的表达及与乳腺钼靶X线征象的关系

Expressions of serum MMP-2 and MMP-9 in the breast cancer and their relationships with molybdenum target X-Ray scanning

目的探讨乳腺癌患者血清中基质金属蛋白酶(MMP)-2和MMP-9的表达及与乳腺钼靶X线征象的关系。方法采用双抗体夹心ELISA法检测85例乳腺癌患者MMP-2、MMP-9的表达,并对所有患者进行乳腺钼靶X线扫描,然后分析两者表达与乳腺钼靶X线主要征象的关系。结果乳腺癌患者血清中MMP-2、MMP-9的表达水平分别为(113.41±10.22)μg/L、(174.27±10.97)μg/L。乳腺癌患者血清中MMP-2、MMP-9的表达水平与毛刺征、钙化征、淋巴结转移征关系密切(P<0.05)。结论 MMP-2、MMP-9的高表达是乳腺癌预后较差的预后因子,且两者均与毛刺征、钙化征、淋巴结转移征阳性关系密切,可能是其阳性征象的组织病理学基础。

Objective To investigate the expressions of serum matrix metalloproteinases （MMP） -2 and MMP-9 in the breast cancer, and to analyze their relationships with molybdenum target X-ray scanning. Methods A double antibody sandwich ELISA assay was used to detected the serum MMP-2 and MMP-9 in the 85 patients with breast cancer, and all the patients received the molybdenum target X-ray scanning, and the relationship with molybdenum target X-ray imaging were analyzed. Results The expression levels of serum MMP-2 and MMP-9 in the breast cancer were （113.41＆#177;10.22） and （174.27＆#177;10.97）μg/L, respectively. The expressions of serum MMP-2 and MMP-9 were related with burr syndrome, calcification and lymph node metastasis （P＆lt;0.05）. Conclusion High expressions of MMP-2 and MMP-9 are the signs of poor grognosis of breast cancer, and their high expressions are positively related with positive burr syndrome, positive calcification and positive lymph node metastasis, and they can be pathology basis of the positive signs.