CD40和CD226基因多态性与类风湿性关节炎易感性的Meta分析

Polymorphisms of CD40 and CD226 associate with risk of rheumatoid arthritis: a meta-analysis

目的探讨CD40 rs4810485 G/T多态和CD226 rs763361 C/T(Gly307Ser)多态与类风湿性关节炎(RA)发病风险的关系。方法使用PubMed/MEDLINE和Embase数据库检索2013年5月以前所有相关文献。两名研究者分别独立检索文献、提取有效数据并交叉核对。采用固定或随机效应模型计算优势比(OR)和95%置信区间(CI)对CD40 rs4810485多态和CD226 rs76336多态与RA易感性的关系进行总体评估。采用漏斗图和Egger检验评价发表偏倚。所有分析均使用Stata10.1统计学软件进行处理。结果共有8项独立的研究(包含11520例RA病例和10843名对照者)被纳入当前的Meta分析。与携带CD40 GG基因型的人相比,携带TT基因型可以显著降低RA的发病风险(OR=0.83,95%CI=0.74-0.94,P<0.01)。与携带CD226 CC基因型的个体相比,携带TT基因型的个体患RA的风险增加46%(OR=1.46,95%CI=1.20-1.77,P<0.01)。当前的Meta分析的数据不存在发表偏倚。结论 CD40 rs4810485和CD226 rs763361多态与RA发病风险显著相关。

Objective To assess the relationship between the risk of rheumatoid arthritis （RA） and the polymorphisms of CD40 rs4810485 G/T and CD226 rs763361 C/T （Gly307Ser）. Methods The PubMed/MEDLINE and Embase databases were searched for all the relevant studies published before May 2013. Two investigators independently searched the databases, extracted data, and reached a consensus on all the items. The odds ratio（OR） and 95% confidence interval （CI） were calculated by either the fixed model or the random model to assess the statistical analyses were performed by Stata 10.1 statistical software. Results Eight studies （including 11520 RA cases and 10843 controls） were enrolled in the meta analysis. The results of the meta analysis showed that the CD40 rs4810485 G/T polymorphisms was associated with decreased risk of RA （TT vs. GG： OR=0.83, 95% CI=0.74-0.94, P=0.004）; compared with the individuals carrying the CD226 CC genotype, the individuals carrying TT genotype had a 46% increased risk of RA （OR=1.46, 95% CI=1.20-1.77, P〈0.001）. In addition, no publication bias was detected. Conclusion The CD40 rs4810485 G/T and CD226 rs763361 C/T （Gly307Ser） polymorphisms were significantly associated with the risk of RA.