恶性肿瘤患者紫杉醇药物化疗后心电图异常分析

Analysis of Abnormal Electrocardiogram of Patients with Malignant Tumors after Chemotherapy with Paclitaxel

目的:分析恶性肿瘤患者在紫杉醇药物化疗前后心电图的改变。方法:记录130例恶性肿瘤患者化疗前、化疗后7 d心电图检查情况,观察窦性心动过速、室性早搏、心房颤动、非特异性ST-T段改变及QRS波群低电压等心电图变化。结果:所有患者接受含紫杉醇药物化疗前均无心电图异常;化疗后,50例患者出现了心电图异常(38.46%),其中<40岁年龄段患者心电图异常发生率明显低于其他各年龄段,差异有统计学意义(P<0.05);化疗第3、4周期后心电图异常发生率明显高于第1、2周期(P<0.05);不同肿瘤类型患者心电图改变比较,差异无统计学意义(P>0.05)。结论:紫杉醇化疗药物对心脏有一定的毒性作用,用其化疗所致的心电图异常发生率随患者年龄的增加而增加,并随化疗疗程的延长呈递增趋势。

Objective：To explore the electrocardiogram changes of patients with malignant tumors before and after chemotherapy with paclitaxel. Method：Recorded the electrocardiograph data of the 130 patients with malignant tumors before and 7 days after chemotherapy,and analyzed the electrocardiogram changes including sinus tachycardia,ventricular premature beat,atrial fibrillation,ST-T segment changes and low QRS voltages,et al.Result：There were no abnormal electrocardiograms before the patients received chemotherapy.50 patients were abnormal electrocardiograms after chemotherapy（38.46%）.The incidence of abnormal electrocardiograms in the group aged less 40 years was lower than the other groups（P＆lt;0.05）.The incidence of abnormal electrocardiogram after the 3rd and 4th chemotherapy cycle was higher than the 1st and 2nd cycle（P＆lt;0.05）.There were no significant electrocardiogram changes between the patients with different tumors（P＆gt;0.05）.Conclusion：Chemotherapy with paclitaxel could induce eardiotoxicity.The incidence of abnormal electrocardiogram is increased when patients with age older as well as the chemotherapy prolong.