2009-2010年我院肺部感染病原菌分布与耐药性分析

Analysis of Lung Infection Pathogen Distribution and Drug Resistance in Our Hospital from 2009 to 2010

目的:了解肺部感染病原菌的分布及耐药性等病原学特点,为临床合理选用抗菌药物提供依据。方法:收集并回顾性分析笔者所在医院符合肺部感染治疗标准的360例感染患者临床资料,进行病原菌培养和药物敏感试验并对结果进行分析。结果:360例感染患者共培养出菌株210株,检出率为58.3%,病原菌中以革兰氏阴性杆菌感染为主;主要以肺炎克雷伯菌、大肠埃希菌和鲍曼不动杆菌为主,分别为22.9%、19.1%、13.8%;在革兰氏阳性菌感染中以葡萄球菌和肺炎链球菌为主,分别为6.2%、3.8%;真菌感染占12.8%,主要为白假丝酵母菌。且革兰氏阴性杆菌产ESBLs的耐药性明显高于非产ESBLs的耐药性。结论:肺部感染需要监测病原菌的种类和药敏变化,真菌感染率上升,多重耐药菌增加,临床医师需密切关注分离菌的变迁及耐药情况,合理使用抗菌药物。

Objective： To investigate the pathogenic bacteria distribution and drug resistance of pulmonary infection, in order to provide basis for clinical reasonable use of antimicrobial drugs.Method ： Collected and retrospectively analyzed the clinical data of 360 cases of infection with the standard treatment of patients were pulmonary infection, the results of pathogenic bacteria culture and drug sensitivity tests were analyzed.Result： 360 cases of infected patients were cultured 210 strains, the positive rate was 58.3%, the pathogenic bacteria were gram-negative bacilli infection; mainly in klebsiella pneumoniac, eschefichia coli and bauman Acinetohaeter, respectively 22.9%, 19.1%, 13.8%; Staphylococcus aureus and streptococcus pneumoniae in Gram-positive bacteria infection, were 6.2%, 3.8%; Fungal infection accounted for 12.8%, mainly for candida albieans.Drug resistance of gram-negative bacilli and drug resistance of ESBLs was significantly higher than that of ESBLs.Conclusion： Distribution and drug resistance of pathogenic bacteria to monitor changes in pulmonary infection, fungal infection rates rose, multiple drug-resistant bacteria increased, and the clinician should pay close attention to the changes and separation of drug-resistant bacteria, and rational use of antimicrohial agents.