新型N-(3-醛基-4-羟基苄基)型季铵盐的合成及其抗菌活性

Synthesis and Antibacterial Activities of Novel N-(3-aldehyde-4-hydroxybenzyl) quaternary Ammonium Salts

5-氯甲基水杨醛和季铵(1a^1e)或吡啶(1f)在乙酸乙酯存在下经取代反应合成了一系列新型的N-(3-醛基-4-羟基苄基)型季铵盐(2a^2f),其结构经1H NMR,IR和MS表征。初步的抗菌活性测试结果表明,2a^2f对迟钝爱德华菌、嗜水气单胞菌、哈氏弧菌和鳗弧菌的MIC分别为0.18 mg·mL-1,0.09 mg·mL-1,0.18mg·mL-1和0.09 mg·mL-1。

A series of novel N-（3-aldehyde-4-hydroxybenzyl） quaternary ammonium salts （2a ～ 2f） containing salicylaldehyde were synthesized by substitution reaction of 5-cholromethylsalicylaldehyde with tertiary amines（1a ～ 1f） or pyridine（1f）.The structures were characterized by 1H NMR,IR and MS.The preliminary antibacterial activities tests indicated that MIC of 2a ～ 2f against Edwardsiella tarda,Aeromonas hydrophila,Vibrio harveyi and Vibrio anguillarum were 0.18 mg · mL-1,0.09 mg · mL-1,0.18 mg· mL-1,and 0.09 mg· mL-1,respectively.