3β-对甲酰氨基己酸苯甲酰氧基熊果烷-12-烯-28-羧基甲酯的合成

Synthesis of 4'-(N-pentane carboxyl amide)-1'-ursolic Methyl Ester-3β-yl-benzoate

以熊果酸为原料,通过对28-位羧基进行酯化保护反应,3-位羟基引入对甲酰氯苯甲酰基,再与氨基己酸反应引入个一个长的间隔臂,合成了一个新型的手性选择物———3β-对甲酰氨基己酸苯甲酰氧基熊果烷-12-烯-28-羧基甲酯,其结构经1H NMR,13C NMR和ESI-MS表征。

A novel terpenoid chiral selector,4＇-（N-pentane carboxyl amide）-1 ＇-ursolic methyl ester3β-yl-benzoate,was synthesized from ursolic acid by esterification of 28-position carboxyl group,derivatization of 3-position hydroxyl group with paraphthaloyl chloride and addition of a long spacer with 6-aminocapmic acid.The structure was characterized by 1H NMR,13C NMR and ESI-MS.