(R)-α-苯乙胺拆分全顺式-3-N-叔丁氧羰基氨基-5-甲氧羰基环己基甲酸

Resolution of cis,cis-3-N-tert-butoxycarbonyl-5-methoxycarbonylcyclohexanecarboxylic Acid by( R)-α-phenethylamine

以光学活性(R)-α-苯乙胺(1)为拆分剂,将cis,cis-3-N-叔丁氧羰基氨基-5-甲氧羰基环己基甲酸[(±)-2]拆分为cis,cis-(-)-2,其结构经1H NMR和13C NMR确证。最佳拆分条件为:以丙酮为溶剂,n(1)∶n[(±)-2]=1.0∶1.0,拆分效率34.1%。

cis,cis-3-N-tert-butoxycarbonyl-5-methoxycarbonylcyclohexane carboxylic acid [（±）-2] was resoluted to cis,cis-（-）-2 using （R）-α-phenethylamine （1） as the resolution agent.The structure was confirmed by 1H NMR and 13C NMR.The optimum resolution condition were as follows：n （1） ∶ n[（±）-2] =1.0 ∶ 1.0,acetone was solvent.The resolution effiency was 34.1% under the optimum resolution conditions.