摘要
提出了一种以碳酸钾为非均相固体碱催化剂的通过三组分Gewald反应一锅法简易高效合成2-氨基-3-氰基-4,5,6,7-四氢苯并[b]噻吩的新方法。考察了催化剂用量、反应时间和溶剂类型对目标产物收率的影响,确定最佳反应条件如下:催化剂用量为20%(摩尔分数),反应时间为3.0h,溶剂为乙醇。该方法具有催化剂价廉高效、分离纯化简单、反应时间短以及产物收率高等优点。
A facile and high-efficient one-pot procedure for synthesis of 2-amino-4,5,6,7-tetrahydrobenzo [b]thiophene-3-carbonitrile via Gewald's three-component reaction with potassium carbonate as a heterogeneous solid base catalyst has been developed.The effects of catalyst dosage,reaction time and solvent type on the product yield are studied.The optimum reaction conditions are identified as follows:the catalyst dosage is 20% (molar fraction),the reaction time is 3.0 h and the solvent is ethanol.This method has advantages of cheap and high-efficient catalyst,simple purification,short reaction time and high product yield.
出处
《化学与生物工程》
CAS
2014年第3期24-27,共4页
Chemistry & Bioengineering
基金
国家自然科学基金资助项目(201262012)
湖北省教育厅科研项目(B20101901)