对氯苯乙酸的合成

Synthesis of p-Chlorophenylacetate Acid

以对氯苯乙腈为原料直接经硫酸催化水解合成对氯苯乙酸,通过对传统工艺的重新设计,得到了适合工业化的新工艺,优化的合成条件为：硫酸质量分数60％～70％、反应时间3h、反应温度130～140℃,对氯笨乙酸收率达95％左右.

p-Chlorophenylacetate acid was prepared by hydrolysis from p-chlorobenzyl cyanide catalyzed by sulfuric acid.By redesigning the traditional method,the process suitable for industrial manufacture was obtained,the optimal synthetic conditions were as follows：mass fraction of sulfuric acid of 60 ％ ～ 70 ％,reaction time of 3 h,reaction temperature of 130 ～ 140 ℃,and the yield of p-chlorophenylacetate acid reached about 95％.