摘要
目的:观察咪唑斯汀缓释片联合孟鲁斯特治疗泛发性湿疹的疗效。方法:105例泛发性湿疹患者通过随机程序分为治疗组(53例)与对照组(52例)。对照组给予口服咪唑斯汀缓释片10 mg,qd;治疗组在对照组的基础上加用孟鲁司特10 mg,qd;两组均外用糠酸莫米松软膏,bid,疗程均为6周。依据患者治疗前后皮损变化情况进行评分。结果:有5例未能完成疗程,治疗组与对照组的有效率分别为94.0%、70.0%,治疗组症状积分明显小于对照组,差异均有统计学意义(P<0.05)。治疗过程中有患者出现口干、嗜睡等症状,不良反应轻微,差异无统计学意义(P>0.05)。结论:咪唑斯汀缓释片联合孟鲁司特治疗泛发性湿疹是一种安全、有效的治疗方法。
OBJECTIVE: To observe the efficacy of montelukast combined with Mizolastine sustained-release tablets in the treatment of eczemauniversale. METHODS: 105 patients with eczemauniversale were randomly divided into treatment group (53 cases) and control group (52 cases). Control group was given Mizolastine sustained-release tablets orally 10 mg,qd a day; treat- ment group was additionally given montelukast 10 mg, qd on the basis of control group. Both groups received Momestasone furoate cream for external use twice a day for 6 weeks. The differences of skin lesions were scored before and after treatment. RESULTS: There were 5 cases failed to complete the test during treatment. The effective rate was 94.0% for treatment group and 70.0% for control group; the symptom score of treatment group was significantly lower than that of control group; there was statistical differ- ences (P〈0.05). During the treatment, some patients suffered from dry mouth, drowsiness and other symptoms; but the adverse reactions were slight; there was no statistical significance (P〉0.05). CONCLUSIONS: Montelukast combined with Mizolastine sustained-release tablets can effectively cure the eczemauniversale.
出处
《中国药房》
CAS
CSCD
2014年第14期1296-1297,共2页
China Pharmacy