咪唑斯汀缓释片联合孟鲁司特治疗泛发性湿疹的疗效观察

Efficacy Observation of Mizolastine Sustained-release Tablets Combined with Montelukast in the Treatment of Eczemauniversale

目的:观察咪唑斯汀缓释片联合孟鲁斯特治疗泛发性湿疹的疗效。方法:105例泛发性湿疹患者通过随机程序分为治疗组(53例)与对照组(52例)。对照组给予口服咪唑斯汀缓释片10 mg,qd;治疗组在对照组的基础上加用孟鲁司特10 mg,qd;两组均外用糠酸莫米松软膏,bid,疗程均为6周。依据患者治疗前后皮损变化情况进行评分。结果:有5例未能完成疗程,治疗组与对照组的有效率分别为94.0%、70.0%,治疗组症状积分明显小于对照组,差异均有统计学意义(P<0.05)。治疗过程中有患者出现口干、嗜睡等症状,不良反应轻微,差异无统计学意义(P>0.05)。结论:咪唑斯汀缓释片联合孟鲁司特治疗泛发性湿疹是一种安全、有效的治疗方法。

OBJECTIVE： To observe the efficacy of montelukast combined with Mizolastine sustained-release tablets in the treatment of eczemauniversale. METHODS： 105 patients with eczemauniversale were randomly divided into treatment group （53 cases） and control group （52 cases）. Control group was given Mizolastine sustained-release tablets orally 10 mg,qd a day; treat- ment group was additionally given montelukast 10 mg, qd on the basis of control group. Both groups received Momestasone furoate cream for external use twice a day for 6 weeks. The differences of skin lesions were scored before and after treatment. RESULTS： There were 5 cases failed to complete the test during treatment. The effective rate was 94.0% for treatment group and 70.0% for control group; the symptom score of treatment group was significantly lower than that of control group; there was statistical differ- ences （P〈0.05）. During the treatment, some patients suffered from dry mouth, drowsiness and other symptoms; but the adverse reactions were slight; there was no statistical significance （P〉0.05）. CONCLUSIONS： Montelukast combined with Mizolastine sustained-release tablets can effectively cure the eczemauniversale.