Livin、Caspase-9在十二指肠腺癌中的表达及临床意义

The expression and clinical significance of Livin and Caspase-9 in duodenal adenocarcinoma

采用免疫组化法检测60例十二指肠腺癌组织及30例癌旁正常组织中凋亡抑制蛋白Livin和半胱氨酸天冬氨酸蛋白酶-9(Caspase-9)的表达。结果显示十二指肠腺癌标本Livin和Caspase-9的阳性表达率分别为71.7%、25.0%,与癌旁正常组织阳性表达率(26.7%、76.7%)差异有统计学意义(P<0.01)。Livin的表达随着十二指肠腺癌病变化进展、程度的发展,阳性表达率增高,Caspase-9的表达随着十二指肠腺癌病理变程度的发展,阳性表达率降低,两者比较差异有统计学意义(P<0.05,r=-0.320)。十二指肠腺癌组织标本中Livin和Caspase-9的表达呈负相关性。Livin和Caspase-9在十二指肠腺癌的发生、发展中起着重要的作用,可能会成为十二指肠腺癌的分子标志物或十二指肠腺癌治疗的新分子靶点。

The expressions of Livin and Caspase-9 were detected by immunohistochemical technique in 60 duode-nal adenocarcinoma tissues and 30 adjacent normal tissue. The positive expression rate of Livin in duodenal adeno-carcinoma tissues was significantly higher than that of adjacent normal tissue,and the expression of Caspase-9 was lower than that of adjacent normal tissue （ P〈0.01 ） . The expression of Livin was negatively correlated with the ex-pression of Caspase-9 （ P〈0.01 ） . The expression of Livin and Caspase-9 was closely correlated with the progress of pathological changes, degree of development,lymph nods metastasis,and clinical stages,but not with sex,age and tumor size （ P〉0.05 ） . Livin and Caspase-9 were associated with occurrence and development of duodenal adeno-carcinoma,and the expression of the above two were negatively correlated. Livin and Caspase-9 may be considered as reliable markers for clinical diagnosis,therapy efficacy and the prognosis of duodenal adenocarcinoma.