乳酸乳球菌表面展示技术中锚定基序应用的研究进展

Advance in research on application of anchor motif in Lactococcus lactis surface display technology

目的乳酸乳球菌(Lactococcus lactis,L.lactis)作为公认的食品安全级微生物,已被用于生活的诸多方面。表面展示技术的发展为L.lactis在活菌疫苗、疾病诊断及固定化酶等方面的研究带来了全新的方向。但在L.lactis表面展示的过程中存在较多问题,其中之一就是锚定基序的选择。本文主要就L.lactis表面展示系统中锚定基序的选择及应用作一综述。

Lactococcus lactis is generally regarded as a safe microorganism and has been used in many aspects. With the development of surface display technology, L. lactis can be better applied in the research of live vaccine, disease and immobilization of enzymes. However, there are still several problems in the L. lactis surface display technology, one of which the selection of a suitable anchor motif. In this paper, we introduced and summarized the selection and aoolication of anchor motif in L. lactis surface disolav technolozv.