摘要
采用meta分析系统评价甲状腺球蛋白基因多态性与自身免疫性甲状腺疾病（AITD）易感性的关系。共纳入8项病例对照研究，E33SNP及E12SNP与亚洲人AITD的OR分别为1．54（95％CI1．21～1．97，P=0．024）及1．12（95％CI1．05～1．21，P=0．033）。甲状腺球蛋白基因多态性与AITD可能相关。
The association between thyroglobulin gene polymorphism and autoimmune thyroid disease was investigated. A total of eight case-control studies were included. E33SNP was associated with increased susceptibility of autoimmune thyroid disease in recessive model（ OR= 1.54, 95% CI 1.21 ～ 1.97, P=0.024） , while E12SNP was associated with increased susceptibility of autoimmune thyroid disease in allele model （ OR = 1. 12, 95% CI 1.05 ～1.21, P = 0. 033 ）. Thyroglobulin gene polymorphism seems to be associated with autoimmune thyroid disease.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2014年第3期221-224,共4页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（81270369）
