药物依从性影响因素及策略分析

Analysis of factors influencing and strategies improving drug adherence

患者是否能按照治疗方案服用药物,即药物治疗依从性,直接关系到治疗效果和药物评价。研究表明,药物的不依从性与不良临床结局指标和高额医疗费用密切相关;在药物临床评价试验中,受试者服药依从性直接影响药物有效性和安全性的评价,关乎新药审批及合理用药方案的制定。因此,对患者服药依从性进行研究具有重要的临床意义。影响服药依从性的因素较多且复杂,本文通过对相关研究资料的汇总分析,阐述药物依从性的相关影响因素和提高策略,为制定相关对策提供参考。

Drug adherence was objective to evaluate whether patients obeyed the therapeutic schedule and complied with drugs. Drug adherence directly influenced treatment effect and clinical drug evaluation. Studies demonstrated that non drug adherence was associated with adverse clinical outcomes and high medical cost. Drug adherence affected the efficacy and safety of the intervention drug in clinical trials. It posed an impact on new drug approval and the rationale drug use. Therefore, it was significant to study drug adherence. Factors affecting drug adherence were diversity. This paper summarized the related information, clarified affecting factors and provided strategies for improving medication adherence to lay foundation for establishing relevant regulations.