期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胃癌和正常胃黏膜上NAG-1表达的比较 被引量：3

下载PDF
导出
摘要 目的探索NAG-1在胃癌、癌旁正常组织和正常胃黏膜上的表达情况及在胃癌发生发展中的作用。方法采用免疫组化SP法、RT-PCR法检测胃癌组织、癌周正常组织及正常胃黏膜上NAG-1蛋白及mRNA的表达。结果 NAG-1蛋白在癌旁正常组织表达较强,高于正常胃黏膜及胃癌NAG-1蛋白表达量,NAG-1蛋白在正常胃黏膜表达量高于胃癌;NAG-1mRNA在癌旁正常组织的表达量高于正常胃黏膜及胃癌,NAG-1mRNA在正常胃黏膜表达量高于胃癌;NAG-1蛋白在中高分化胃癌表达量高于低分化胃癌;相关性分析发现:NAG-1蛋白表达与胃癌的浸润程度、TNM分期及肿瘤大小无明显相关性。结论 NAG-1在胃癌的发生发展中可能扮演抑癌基因的角色,其表达的减弱或缺失可能导致胃癌发生。
作者 杨公利 谭庆华 谢咏梅 郭梅梅 李静 唐承薇 王春晖
机构地区 四川大学华西医院消化内科 湖北医药学院附属太和医院消化内科
出处 《现代消化及介入诊疗》 2014年第1期51-54,共4页 Modern Interventional Diagnosis and Treatment in Gastroenterology
基金 四川省科技厅科研项目(04SG022-015-05)
关键词 胃癌 非甾体抗炎药物 NAG-1 COX-2 抑癌基因
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1Baek SJ, Kim KS, Nixon JB, et al. Cyclooxygenase inhibitors regulate the expression of a TGF -beta superfamily member that has proapoptotic and antitumorigenic activities. Mol Phannacol, 2001, 59(4):901-908.
  • 2Li PX, Wong J, Ayed A, et al. Placental transforming growth factorbeta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. J Bioi Chem, 2000,275(26):20127-20135.
  • 3Bootcov MR, Bauskin AR, Valenzuela SM, et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF- beta superfamily. Proc Natl Acad Sci USA, 1997,94(21):11514- 11519.
  • 4Hromas R, Hufford M, Sutton J, et al. PLAB, a novel placental bone morphogenetic protein. Biochim Biophys Acta, 1997,1354(1):40- 44.
  • 5Paralkar VM, Vail AL, Grasser W A, et al. Cloning and characterization of a novel member of the transforming growth factor-betaibone morphogenetic protein family. J Bioi Chem, 1998,273(22):13760- 13767.
  • 6Bottner M, Laaff M, Schechinger B, et al. Characterization of the rat, mouse, and human genes of growth/differentiation factor -151 macrophage inhibiting cytokine-1 (GDF-15/MIC-l). Gene, 1999, 237(1):105-111.
  • 7Baek SJ, Wilson LC, Eling TE. Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Carcinogenesis, 2002,23(3): 425-434.
  • 8Wilson LC, Baek SJ, Call A, et al. Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells. Int J Cancer, 2003,105 (6):747-753.
  • 9Bottone FG Jr, Baek SJ, Nixon.JB,et al. Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells. J Nutr, 2002,132(4):773-778.
  • 10Lee SH, Kim JS, Yamaguchi K, et al. Indole-3-carbinol and 3,3'diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem Biophys Res Commun, 2005,328(1):63-69.

同被引文献50

引证文献3

二级引证文献16

现代消化及介入诊疗
2014年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部