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结合蛋白TDP-43与神经变性疾病 被引量：5

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摘要 TDP43（transactive DNA bindingprotein43）是一个多功能的DNA和RNA结合蛋白，在RNA转录、选择性剪接及mRNA稳定性调节等过程中发挥作用。它是大部分额颞叶变性（FTLD）和肌萎缩侧索硬化（ALS）的主要病理学标志，是FFLD和ALS患者残存神经元内泛素化包涵体的特征性成分。此外，TDP43也见于其他神经变性疾病，包括阿尔茨海默病（AD）、帕金森病”刮等。我们拟对TDP43的生理功能，TDP43与FTLD、ALS及其他神经变性疾病的关系，以及其在兀1LD和ALS发病机制中的作用进行综述。
作者 邓燕芬 刘运海 田田
机构地区 湖南省郴州市第四人民医院神经内科 中南大学湘雅医院神经内科 郑州大学第一附属医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2014年第3期195-198,共4页 Chinese Journal of Neurology
基金 国家自然科学青年基金资助项目（81301087）
关键词 神经变性疾病 RNA结合蛋白 肌萎缩侧索硬化 阿尔茨海默病 RNA转录 选择性剪接 特征性成分 ALS
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献60

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二级参考文献23

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共引文献7

同被引文献48

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引证文献5

二级引证文献17

中华神经科杂志
2014年 第3期

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