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胰岛移植治疗1型糖尿病的过去、现在和未来 被引量：4

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摘要 1型糖尿病（T1DM）是一种自身免疫性疾病,在胰岛素问世之前,T1 DM患者从发病到死亡的时间在儿童不足1年、成人不足4年,胰岛素的发现使得T1 DM从致死性疾病转变为慢性疾病.美国糖尿病学会糖尿病控制与并发症研究（DCCT）显示,通过胰岛素强化治疗可显著降低糖尿病视网膜病变、神经病变和肾脏病变进展,但不能避免胰岛功能的持续下降并最终出现血糖剧烈波动的＂脆性糖尿病＂的出现.
作者 杨涛 张梅
机构地区 南京医科大学第一附属医院内分泌科
出处 《中华糖尿病杂志》 CAS CSCD 2014年第2期73-76,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
关键词 胰岛素强化治疗 1型糖尿病 移植治疗 糖尿病视网膜病变 自身免疫性疾病 美国糖尿病学会 糖尿病控制 脆性糖尿病
分类号 R587.1 [医药卫生—内分泌]
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参考文献29

  • 1Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid- free immunosuppressive regimen[ J]. N Engl J Med, 2000, 343: 230-238.
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同被引文献28

  • 1郭君其,周晓丹,杨晓玲,付乐华,陶小琴,谭建明,吴志贤.我国首例成人胰岛细胞肝内移植术的观察与护理[J].解放军护理杂志,2007,24(4):92-94. 被引量：5
  • 2谭建明.成人胰岛细胞移植治疗糖尿病的现状与发展[J].中国实用内科杂志,2007,27(7):537-541. 被引量：10
  • 3Nishimura R,Nishioka S,Fujisawa I,et al.Tacrolimus inhibits the revascularization of isolated pancreatic islets[J].PLoS One,2013,8:e56799.
  • 4Fukami N,Subramanian V,Angaswamy N,et al.Mizoribine-an inosine monophosphate dehydrogenase inhibitor-acts synergistically with cyclosporine a in prolonging surival of murine islet cell and heart transplants across major histocompatibility barrier[J].Transpl Immunol,2012,26:140-145.
  • 5Niclauss N,Bosco D,Morel P,et al.Rapamycin impairs proliferation of transplanted islet β cells[J].Transplantation,2011,91:714-722.
  • 6Johnson JD,Ao Z,Ao P,et al.Different effects of FK506,rapamycin,and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets[J].Cell Transplant,2009,18:833-845.
  • 7Khattar M,Deng R,Kahan BD,et al.Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts[J].Transplantation,2013,95:919-927.
  • 8Hire K,Ngo DK,Stewart-Maynard KM,et al.Foxp3±,and not CD25 +,T eells increase post-transplant in islet allotransplant recipients following anti-CD25 + ratg immunotherapy[J].Cell lmmunol,2012,274:83-88.
  • 9Herold KC,Gitelman SE,Willi SM,et al.Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period:a randomised controlled trial[J].Diabetologia,2013,56:391-400.
  • 10Watanabe T,Masuyama J,Sohma Y,et al.CD52 is a novel eostimulatory molecule for induction of CD4+ regulatory T cells[J].Clin lmmunol,2006,120:247-259.

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中华糖尿病杂志
2014年 第2期

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