p53在乳腺癌中的表达及其临床意义

The expression of p53 in breast cancer and its clinical significance

目的探讨p53蛋白在乳腺癌中的表达及其临床意义。方法收集该科收治的214例乳腺癌患者的临床病理资料,回顾性分析p53蛋白表达情况及其与临床病理特征的相关性。结果 p53蛋白阳性率为52.3%;p53阳性表达与患病年龄、病灶大小无相关性(P>0.05),与淋巴结转移状态、肿瘤组织学分级及分子分型呈正相关(r=0.396、0.309、0.167,P=0.000、0.000、0.014),与雌激素受体、孕激素受体的表达呈负相关(r=-0.561、-0.315,P=0.000、0.000),与人表皮生长因子受体2及Ki-67的表达呈正相关(r=0.374、0.153,P=0.000、0.026);三阴型与非三阴型中p53蛋白表达差异有统计学意义(P<0.05)。结论p53与乳腺癌生物学特性密切相关,检测乳腺癌中p53的表达可作为指导临床治疗和判断预后的参考指标。

Objective To investigate the expression of p53 in breast cancer and its clinical significance .Methods The clinical pathological data of 214 cases of breast cancer patients were collected ,and retrospective analyzed of p53 protein expression and its correlation with clinical pathological features .Results The positive rate of p53 was 52 .3% .The expression p53 was no correlation with age ,the size of the lesion（P＆gt; 0 .05） ,it was correlation with lymph node metastasis ,histological classification and molecular subtype（r=0 .396 ,0 .309 ,0 .167 ,P=0 .000 ,0 .000 ,0 .014） ,and also have negative correlation with the expression rate of ER ,PR （r= -0 .561 ,-0 .315 ,P=0 .000 ,0 .000） ,positive correlation with HER2 and Ki67（r=0 .374 ,0 .153 ,P=0 .000 ,0 .026） .In the group of triple negative breast cancer （TNBC） and the group of non-TNBC ,the difference was statistically significant of expression of p53 （P＆lt;0 .05） .Conclusion p53 protein has closely related with the development ,relapse and metastases of breast cancer ,the detection of p53 can be used to guide the individualized therapy and as a reference index to evaluate the prognosis of breast cancer .