血清心肌酶谱、C-反应蛋白和血小板计数变化在儿童支气管肺炎中的意义

The significance of myocardial enzyme,C-reactive protein and platelet count in children with bronchial pneumonia

目的探讨血清心肌酶谱、C-反应蛋白(CRP)和血小板计数与儿童支气管肺炎的关系。方法选择2010年8月至2012年12月该院确诊为支气管肺炎的1 000例患儿为研究对象(支气管肺炎组),根据患儿的临床症状严重程度分为轻症肺炎组和重症肺炎组;并以1 000例健康体检儿童为对照(对照组),分别测定其血液心肌酶谱、CRP和血小板的变化情况。结果支气管肺炎组心肌酶谱指标:天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、a-羟丁酸脱氢酶(α-HBDH)、血清肌酸激酶(CK)、CK同工酶(CK-MB),血小板计数值和CRP水平均显著高于对照组,差异有统计学意义(P<0.05);而在重症肺炎组中,AST、LDH、α-HBDH、CK、CK-MB、血小板计数和CRP的升高比例亦显著显著高于轻症肺炎组,差异有统计学意义(P<0.05)。结论心肌酶谱、CRP和血小板联合检测对支气管肺炎的鉴别和诊断有较高特异度,尤其提高了对重症支气管肺炎鉴别的灵敏度。

Objective To explore the relationship between bronchial pneumonia in children and the level of myocardial enzyme , C-reactive protein （CRP） and platelet count .Methods 1 000 cases of children with bronchial pneumonia from August 2010 to De-cember 2010 were retrospectively analyzed （bronchial pneumonia group） ,According to the clinical symptom severity ,the children wwer divided into mild bronchial pneumonia group and severe bronchial pneumonia .1 000 healthy children were recruited in control group（control group） ,and the changes of myocardial enzyme ,platelet count and CRP were tested .Results The myocardial enzyme , including aminotransferase （AST ） ,lactate dehydrogenase （LDH ） ,a- hydroxybutyric acid dehydrogenase （alpha HBDH ） ,serum creatine kinase （CK） ,CK isoenzyme （CK-MB） ,platelet count and CRP in bronchial pneumonia group were all higher than that of control group （P＆lt;0 .05）;In the severe bronchial pneumonia group ,the increased rate of AST ,LDH ,α-HBDH ,CK ,CK-MB ,plate-let count and CRP indicators were significant higher than that in the mild pneumonia group （P＆lt;0 .05） .Conclusion The determina-tion of myocardial enzyme ,platelet count and CRP would be useful and helpful for the diagnosis of children bronchial pneumonia ,in particular the severe bronchial pneumonia .