C-MYC在涎腺腺样囊性癌中的表达及意义

Expression of C-MYC in salivary adenoid cystic carcinoma and its clinicopathological significance

目的：研究原癌基因C- MYC在涎腺腺样囊性癌（SACC）中的表达及意义。方法应用免疫组化法对54例SACC和20例正常涎腺组织石蜡标本中C- MYC表达水平进行检测并比较。结果20例正常涎腺组织中C- MYC均呈阴性表达，54例SACC标本中C- MYC阳性表达43例，阳性率为79.6%，差异有统计学意义（P＜0.05）。有神经浸润、T4期C- MYC阳性率较无神经浸润、T1-3期高（P＜0.05），C- MYC的表达与年龄、性别、肿瘤部位、组织学类型、远处转移及淋巴结转移等生物学特性的差异均无统计学意义（均P＞0.05）。结论原癌基因C- MYC在SACC中高表达，与T分期及神经侵犯有关，有望成为SACC进展及预后的生物学标志之一。

Objective To investigate the expression of C- MYC in salivary adenoid cystic carcinoma （SACC） and clinico-pathological significance. Methods Immunohistochemisty was used to determine tissue expression of C- MYC in 54 patients with salivary adenoid cystic carcinoma from Zhejiang Provincial Cancer Hospital and 20 samples of normal gland tissue. The clin-icopathological significance of C- MYC expression was analyzed. Results C- MYC was positively expressed in 43 of 54 SACC tissues and none of 20 normal salivary gland tissues with the positive rate was 79.6%and 0.0%, respectively （P〈0.05）. Further-more, C- MYC expression was higher in stage T4 and perineural invasion patients than those with state T1-3 and no perineural in-vasion patients（P〈0.05）. C- MYC expression was not correlated with age, gender, tumor location, lymph node metastasis, distant metastasis and histological type （P〉0.05）. Conclusion The expression of proto- oncogene C- MYC was correlated with T stag-ing and perineural invasion in SACC, incicating that it may be uses as a biological marker for SACC progress and prognosis.