同型半胱氨酸及其代谢因子与维吾尔族妇女子痫前期的相关性研究

Correlation analysis of homocysteine and metabolic factors with preeclampsia

目的 分析维吾尔族子痫前期患者血浆总同型半胱氨酸（tHcy）及其代谢因子叶酸、维生素B12水平与子痫前期病情轻重程度的关系.方法 选择维吾尔族正常晚期妊娠者31例、子痫前期轻度33例、子痫前期重度36例,分别测定其血浆tHcy和血清叶酸、维生素B12水平.结果 血浆tHcy水平在正常对照组、子痫前期轻度组、子痫前期重度组3组之间差异有统计学意义[分别为（9±3）,（13±4）,（16±4） μmol/L]（F=29.688,P＜0.01）,且两两比较差异有统计学意义.叶酸水平3组间差异无统计学意义（F=1.176,P＞0.05）.子痫前期轻度组的维生素B12水平明显低于正常对照组和子痫前期重度组[（154±64） ng/L比（215±79）,（213 ±95） ng/L],差异有统计学意义（P＜0.01）.Pearson相关分析结果显示,3组中血浆tHcy水平与血清叶酸、维生素B12水平之间不具有相关关系（P＞0.05）;Spearman秩相关分析表明,Hcy与子痫前期病情轻重呈正相关（r=0.650,P=0.000）,叶酸、维生素B12与子痫前期病情轻重相关分析无统计学意义（r=0.089,-0.018,P=0.380,0.859）.结论 维吾尔族子痫前期患者的tHcy水平明显增高,tHcy水平与病情轻重程度有关,tHcy水平高者病情重.

Objective To analyze the relationship between the levels of plasma total homocysteine （Hcy） and the metabolic factors of folic acid and vitamin B12 in uygur patients with the severity of preeclampsia.Methods A total of 31 cases of the third trimester of normal pregnancy,33 cases of mild preeclampsia and 36 cases of severe preeclampsia were selected.Results Hcy levels were statistically different among the normal control group,mild preeclampsia group and severe preeclampsia group [（9 ± 3）,（13 ±4）,（16 ±4）μmol/L,respectively] （P ＜ 0.05） ; folate levels were no different among the three groups （F =1.176,P ＞ 0.05）,vitamin B12 levels in mild preeclampsia were lower than that in control group and severe preeclampsia[（154 ±64）ng/L vs （215 ± 79）,（213 ± 95） ng/L] （P ＜ 0.05）.There was no correlation among the Hcy,folic acidand vitamin B12 （P ＞ 0.05）.Hcy with preeclampsia severity was positively correlated,folic acid,vitamin B12 and preeclampsia severity was not correlated,and the difference was statistically significant （P ＞ 0.05）.Conclusion The levels of tHcy is related to the severity of preeclampsia.