352例结缔组织病并间质性肺疾病临床特点分析

Analysis on clinical features of 352 patients with connective tissue diseases and interstitial lung disease

目的本研究通过比较分析结缔组织病并间质性肺疾病（connectivetissuediseaseandinterstitiallungdisease，CTD-ILD）患者的临床特点，旨在提高临床医师对CTD-ILD疾病的认识水平。方法收集并回顾性分析2011年1月1日至2012年12月31日于郑州大学第一附属医院初诊为CTD-ILD的患者的临床特征及影像学特点。结果CTD-ILD患者352例，男女发病比例为1：2．67，平均发病年龄（53．07±13．65）岁。CTD-ILD患者全身症状发生率高于呼吸系统症状。CTD-ILD的高分辨率CT表现多为对称性磨玻璃影、网格状、胸腔积液等改变，主要累及中肺和下肺。结论CTD-ILD多发生于育龄期女性，部分肺部病变首发于CTD症状之前，并可独立进展。高分辨率CT有助于ILD的早期诊断及治疗方案制定。

Objective To investigate the clinical and high resolution computed tomography （HRCT） features of connective tissue diseases and interstitial lung disease （CTD-ILD）,and improve the diagnosis and therapy level of CTD-ILD. Methods The data of patients with CTD-ILD who were hospitalized in the first affiliated hospital of Zhengzhou University from January 1,2011 to December 31, 2012 were collected. The clinical and CT features of the cases were retrospectively analysed. Results There were 352 patients with CTD-ILD. The ratio of the incidence of men and women was 1 .＂ 2.67. The average age was （53.07i 13.65） years old. The incidence of systemic symptoms was higher than that of respiratory symptoms. HRCT manifestatins of CTD-ILD were grinding glass shadow, grid and pleural effusion,which were mainly in low and middle lung zones. Conclusions CTD-ILD mainly occurs in women. The occurrence of some lung diseases is earlier than that of CTD symptoms. HRCT is helpful for early diagnosis and therapy.