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endocan在脓毒血症及其急性肺损伤的研究进展 被引量：2

Development of endocan in sepsis and acute lung injury
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摘要 endocan又名内皮细胞特异性分子-1，最早是由法国科学家Lassalle等从脐静脉内皮细胞cDNA文库克隆出的一种内皮细胞特异性分子，在正常人体内主要由肺、肾脏血管内皮细胞分泌，其影响白细胞的黏附、迁移，并在炎症性疾病及肿瘤的进展中起关键作用。近年研究发现，endocan参与脓毒血症和ALI的病理生理过程，在预测疾病的严重性方面具有积极的临床意义。 endocan is a novel human endothelial cell-specific molecule cloned from human umbrilical vein endothelial cell cDNA library, which was found by Dr. Lassalle from France. Endocan is expressed in endothelial cell of lung and kidney, which can affect adhesion, migration of white blood cells, and play a key role in inflammatory diseases and tumor. In recent years, researchers have found that endocan may be involved in the pathogenesis of sepsis and associated with the development of acute lung injury, and represent the positive clinical significance.
作者 唐玲 王导新
机构地区 重庆医科大学附属第二医院呼吸与危重症医学科
出处 《国际呼吸杂志》 2014年第6期465-467,共3页 International Journal of Respiration
关键词 endocan ESM-1 内皮细胞特异性分子-1 脓毒血症 急性肺损伤 endocan/ESM-1 Endothelial cell-specific molecule-1 Sepsis Acute lung injury
分类号 R459.7 [医药卫生—急诊医学]
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参考文献15

  • 1Bechard D,Gentina T,Delehedde M,et al. Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth{actor/scatter {actor mitogenic activity[J]. J Biol Chem, 2001,276 : 48341-48349.
  • 2Sarrazin S, Adam E, Lyon M, et al. Endocan or endothelial cell specific molecule 1 (ESM-1) :a potential novel endothelial cell marker and a new targetfor cancer therapy[J]. Biochim Biophys Acta, 2006,1765 : 25-37.
  • 3Trowbridge JM,Gallo RL. Dermatan sulfate: new functions from an old glycosaminoglycan[J]. Glycobiology, 2002,12 117R -125R.
  • 4Lassalle P,Molet S,Janin A,et al. ESM-1 is a novel human endothelial cell specific molecule expressed in lung and regulated by cytokines[J]. J Biol Chem, 1996 , 271: 20458 -20464.
  • 5Scherpereel A, Depontieu F, Grigoriu B, et al. Endocan, a new endothelial marker in human sepsis[J]. Crit Care Med, 2006, 34:532- 537.
  • 6Bfchard D, Scherpereel A, Hammad H, et al. Human endothelial-cell specific molecule-1 binds directly to the integrin CDlla/CD18 ( LFA-1 ) and blocks bindingto intercellular adhesion molecule-l[J]. J Immunol, 2001,167: 3099-3106.
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同被引文献22

  • 1吴丽娥,刘鸣,张月辉,赵晓玲,杨杰,谈颂,张世洪,吴波,谭燕,王清芳,王丽春,李伟.缺血性脑卒中TOAST病因分型和预后[J].中华神经科杂志,2004,37(4):292-295. 被引量：87
  • 2Kriszbacher I,Koppan M,Bódis J,et al.Inflammation,atherosclerosis,and coronary artery disease[J].N Engl J Med,2005,353:429-430.
  • 3Balta S,Demirkol S,Celik T,et al.Association between coronary artery ectasia and neutrophil-lymphocyte ratio.Angiology,2013,64:627-632.
  • 4Zhang SM,Zuo L,Zhou Q,et al.Expression and distribution of endocan in human tissue[J].Biotech Histochem,2012,87:172-178.
  • 5Lee W,Ku SK,Kim SW,et al.Endocan elicits severe vascular inflammatory responses in vitro and in vivo.J Cell Physiol,2014,229:620-630.
  • 6Scherpereel A,Depontieu F,Grigoriu B,et al.Endocan,a new endothelial marker in human sepsis.Crit Care Med,2006,34:532-537.
  • 7Pauly D,Hamed S,Behnes M,et al.Endothelia cell-specific molecule-1/endocan:diagnostic and prognostic value in patients suffering from severe sepsis and septic shock.J Crit Care,2016,31:68-75.
  • 8Balta I,Balta S,Koryurek OM,et al.Serum endocan levels as a marker of disease activity in patients with Behcet disease.J Am Acad Dermatol,2014,70:291-296.
  • 9Menon P,Kocher ON,Aird WC,et al.Endothelia cell specific molecule(ESM-1),a novel secreted proteoglycan stimulates vascular smooth muscle cell proliferation and migration.Circulation,2011,124:154-155.
  • 10Balta S,Mikhailidis DP,Demirkol S,et al.Endocan and atherosclerosis.Angiology,2015,66:490.

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国际呼吸杂志
2014年 第6期

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