青年动脉硬化性脑梗死血尿酸、血脂及糖化血红蛋白与脑动脉病变特点分析

Analysis of blood uric acid,blood lipid,glycosylated hemoglobin and cerebral artery lesion characteristics in young patients with arteriosclerotic cerebral infarction

目的探讨青年动脉硬化性脑梗死患者血尿酸、血脂与脑动脉病变特点。方法对2007年12月至2012年12月我院收治的青年(48例)及中老年(450例)动脉硬化脑梗死患者的临床资料进行对比分析;分析血尿酸、血脂等危险因素以及脑动脉病变特点。结果青年组患者男性、血脂异常、吸烟及有家族史的比例高于中老年组;而中老年组患者中有短暂脑缺血发作史、并发糖尿病及高血压病的比例高于青年组患者。青年组患者血尿酸(UA)水平、体质指数(BMI)、总胆固醇(TC)水平高于中老年组患者;青年组患者脑动脉以单支血管病变为主,中老年组患者双支及三支病变所占比例较高(88.7%),两组患者脑动脉病变支的构成比差异有统计学意义。结论青年动脉硬化脑梗死患者的危险因素及脑动脉病变与中老年患者有所不同,控制其吸烟、纠正血尿酸及脂代谢紊乱等有利于防治青年脑梗死。

Objective To investigate the blood uric acid, blood lipid and glycosylated hemoglobin and cerebral artery lesion characteristics in young patients with arteriosclerotic cerebral infarction . Methods Clinical data of 48 youth and 450 aged people with arteriosclerotic cerebral infarction who were admitted to our hospital from December 2007 to December 2012, were analyzed and compared, including risk factors （blood uric acid and blood lipids） as well as cerebral artery lesion characteristics. Results The number of men, the occurance of dyslipidemia, and the number of patients with smoking history and family history in the youth group were higher than those in the aged group. Yet the number of patients with transient ischemic attack history, and complications of diabetes and hypertension in the aged group were higher than those in the youth group. The level of uric acid （ UA）, triglyceride （TC）, and body mass index （BMI） in the youth group were higher than those in the aged group. The main impairment of cerebral artery in the young people group was single vascular lesions, while 88.7% of the aged patients were primarily suffered from double and three lesions, showing a significant difference between the two groups in terms of branch lesion（P 〈 0.01 ）. Conclusion The risk factors and characteristics of cerebral arteries in the youth group and the aged group who were suffered from arteriosclerosis cerebral infarction vary from each other. Controlling of smoking and correcting the confusion of serum uric acid and lipid metabolism could be helpful to the prevention and treatment of cerebral infarction in young patients.