小剂量辛伐他汀对稳定期慢性阻塞性肺疾病患者生活质量的影响

Effect on Small Doses of Simvastatin on Quality of Life of Patients with Chronic Obstructive Pulmonary Disease

目的:观察小剂量辛伐他汀(10 mg/次,每晚1次)为期1年的治疗对中度稳定期慢性阻塞性肺疾病(COPD)患者生活质量的影响。方法:选取符合纳入标准的60例中度稳定期慢性阻塞性肺疾病患者,按照随机数字表法将其分为试验组和对照组各30例,对照组采取常规治疗1年,试验组在常规治疗的基础上加用辛伐他汀10 mg/次,每晚1次,口服1年,记录并比较1年前后两组患者COPD评估测试(CAT)评分。结果:两组患者治疗前CAT评分比较差异无统计学意义(P>0.05),治疗1年后两组CAT评分均明显优于治疗前,且试验组CAT评分明显优于对照组,比较差异均有统计学意义(P<0.05)。结论:小剂量辛伐他汀可以改善COPD患者生活质量,值得在临床上推广。

Objective：To observe the low-dose simvastatin（10 mg/times,once a night） a period of one year of treatment for moderate stable chronic obstructive pulmonary disease（COPD） patients quality of life impact.Method：60 patients with moderate stable chronic obstructive pulmonary disease were randomly divided into the experimental group and the control group,30 cases in each group.The control group was treated with conventional therapy for one year,the experimental group was treated with oral simvastatin 10 mg/times,once a night for 1 year on the basis of conventional therapy.COPD assessment test（CAT） score of the two groups before and after one year were recorded and compared.Result：Before treatment,the CAT scores had no significant differences between the two groups（P〉0.05）,after one year of treatment,CAT scores of the two groups were significantly better than before treatment,and CAT of the experimental group was significantly better than the control group,the differences were statistically significant（P〈0.05）.Conclusion：Low-dose simvastatin can improve the quality of life in patients with COPD,it is worth promoting in clinical practice.