糖耐量减低患者高甘油三酯血症-腰围表型与血清可溶性E-选择素的相关性研究

The Relationship between Hypertriglyceridemic-waist Phenotype and Serum Soluble E-Selectin(Se) in Patients with Impaired Glucose Tolerance

目的:探讨糖耐量减低(IGT)患者高甘油三酯血症-腰围表型(HTWC)与血清可溶性E-选择素(sE)的相关性。方法:收集2012年2月-2013年3月于天津医科大学代谢病医院门诊诊治的360例IGT患者,分为血甘油三酯和腰围正常组(A组)108例、单纯高甘油三酯血症组(B组)72例、单纯腹型肥胖组(C组)108例和HTWC组(D组)72例,比较四组间一般临床资料及血清sE水平。采用多元逐步回归分析血清sE水平升高的危险因素。结果:HTWC组患者血清sE为(17.37±5.72)ng/mL,明显高于其他三组(10.21±6.88)、(13.78±7.50)、(13.98±6.81)ng/mL,比较差异均有统计学意义(P<0.05)。且多元逐步回归分析显示腰围和高甘油三酯血症均是IGT患者血清sE升高的独立危险因素(β=-2.351,P<0.05)。结论:HTWC是糖耐量减低患者血清sE升高的独立危险因素。

Objective：To analyze the relationship between the hypertriglyceridemic-waist phenotype and serum soluble E-selectin（sE） in patients with impaired glucose tolerance.Method：According to the cut point of plasma triglycerides concentration ≥ 1.7 mmol/L,waist circumference ≥ 90 cm in men or ≥ 80 cm in women,360 patients who saw doctors in the Tianjin Daixiebing hospital from February 2012 to March 2013 were divided into four groups：normal waist circumference and triglycerides,normal waist circumference and hypertriglyceridemia,abdominal obesity and normal triglycerides and hypertriglyceridemic-waist（HTWC）group.The comparison of clinical biochemical characteristics and sE between 4 groups was performed.The risk factors of sE was analyzed.Result：The sE level in HTWC group was（17.37±5.72）ng/mL,it was higher than that in other three groups（10.21±6.88）,（13.78±7.50）,（13.98±6.81）ng/mL（P〈0.05）.Moreover,the waist circumference and hypertriglyceridemia were risk factors for the increased sE level in patients with impaired glucose tolerance（β=0.108,0.774,all P〈0.05）.Conclusion：HTWC was an independent risk factor of the increased level of sE in patients with impaired glucose tolerance.