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T细胞酶联免疫斑点试验在儿童结核性疾病中的诊断价值 被引量：10

Diagnostic value of interferon-gamma release assay T-SPOT for childhood tuberculosis
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摘要 评价结核感染T细胞酶联免疫斑点试验（T-SPOT）在儿童结核性疾病中的诊断价值.对2011年7月至2012年6月苏州大学附属儿童医院收治的45例疑诊或待排结核患儿进行T-SPOT检测,并与结核菌素纯蛋白衍生物（PPD）皮肤试验、血结核抗体测定、抗酸杆菌涂片及结核菌DNA-PCR进行比较.T-SPOT的敏感度、特异度分别为92%、95%,明显高于PPD皮肤试验（76%、75%）,差异有统计学意义（P＜0.01）,两者诊断符合率为18/19.T-SPOT的阳性预测值为96%,阴性预测值为90%.T-SPOT是诊断儿童结核性疾病快速、敏感、特异的方法,在结核性疾病早期诊断中有重要价值. To evaluate the diagnostic value of interferon-gamma release assay T-SPOT for childhood tuberculosis. A total of 45 children suspected of tuberculosis at Affiliated Children Hospital, Soochow University were enrolled from July 2011 to June 2012. T-SPOT test was performed and its results were compared with those of PPD test, tuberculosis antibody test, acid-fast bacilli stain and tuberculosis polymerase chain reaction. The sensitivity and specificity of T-SPOT were 92% and 95% respectively. And the values were higher than PPD test （76%, 75%, P 〈 0. 01 ）. The overall concordance rate between two tests was 18/19. Positive and negative predictive values of T-SPOT were 96% and 90% respectively. Thus T-SPOT test is rapid, sensitive and specific for diagnosing tuberculosis. It can be applied for an early diagnosis of tuberculosis in children.
作者 孙秋凤 严永东 陈正荣 王宇清 黄莉 朱灿红 王美娟 季伟
机构地区 苏州大学附属儿童医院呼吸科
出处 《中华全科医师杂志》 2014年第2期127-129,共3页 Chinese Journal of General Practitioners
关键词 结核 儿童 Tuberculosis Child
分类号 R725.1 [医药卫生—儿科]
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参考文献11

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二级参考文献14

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共引文献34

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中华全科医师杂志
2014年 第2期

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