碱性成纤维细胞生长因子对原发性高血压患者颈动脉粥样硬化斑块的影响

Effects of Basic Fibroblast Growth Factor on Carotid Atherosclerosis Plaque in Patients with Essential Hypertension

目的:探讨原发性高血压患者颈动脉粥样硬化斑块与碱性成纤维细胞生长因子(bFGF)的关系及临床意义。方法:研究对象为住院高血压患者共213例,彩色多普勒超声仪检查颈动脉粥样硬化斑块,采用ELISA方法测定bFGF。结果:原发性高血压患者中无论有无斑块血清bFGF水平明显高于正常对照组(P<0.01),有斑块组高于无斑块组(P<0.05);斑块数量越多,bFGF含量越高;混合斑bFGF水平明显高于硬斑(P<0.05)。结论:碱性成纤维细胞生长因子(bFGF)在体内参与动脉粥样硬化形成的病理过程,bFGF的测定对了解病情、判断预后及药物筛选有一定临床意义。

Objective：To discuss the relationship between basic fibroblast growth factor （abbreviated bFGF） and carotid atherosclerosis plaque in patients with essential hypertension and its clinical implication. Methods： To research 213 hospitalized hypertensive patients, whose carotid atherosclerosis plaque was checked with color doppler ultrasonic inspectoscope, arid bFGF was determined with ELISA. Results： Serum level of bFGF in patients with essential hypertension, whether with or without plaque, was obviously higher than that of normal control groups（P 〈0.01）; level of groups with plaque was higher than that of groups without plaque （P 〈0.05）; the more plaque patients got, the higher the contents of bFGF was; level of mixed plaque groups was obviously higher than that of hard plaque groups （P 〈0.05）. Conclusion： bFGF participate in the pathological process of forming atherosclerosis in the body, the determination of which is of certain clinical significance to pathogenetic condition understanding, prognosis in judgement and drug screening.