宫颈癌与人乳头瘤病毒感染、血清可溶性肿瘤坏死因子受体水平相关性研究

The correlations among cervical cancer, human papilloma virus infection and soluble tumor necrosis factor receptors

目的 探究宫颈癌与人乳头瘤病毒（human papilloma virus,HPV）感染及血清可溶性肿瘤坏死因子受体（soluble tumor necrosis factor receptors,STNFR）水平之间的相关性.方法 将53例宫颈癌患者纳入病例组,50名体检健康者纳入对照组,收集并比较她们的临床资料、HPV感染状况、术前与术后的STNFR水平.结果 病例组HPV感染率为62.26％,高于对照组的HPV感染率（16.00％）,两者差异有统计学意义（P＜0.01）.在病例组中,术前HPV感染阳性患者血清中的STN-FR Ⅰ与STNFRⅡ水平（2210.52±1213.71pg· ml^-1与3679.24±1088.15pg· m1-1）高于HPV感染阴性患者（1149.34 ±603.14pg· ml^-1与2667.23±819.87pg· ml^-1）,差异有统计学意义（STNFRI：P=0.043；STNFRⅡ：P=0.047）；但术后HPV感染阳性与阴性者的STNFR Ⅰ与STNFRⅡ水平差异无统计学意义.病例组患者术后三个月血清STNFR Ⅰ（1080.31±249.67pg· ml^-1）与STNFRⅡ水平（1896.32 ±211.75pg· ml^-1）低于术前（STNFR I：1822.36±1128.16pg· ml^-1,STNFRⅡ：3293.14±1021.58pg· ml^-1）,差异有统计学意义（STNFRI：P=0.039,STNFRⅡ：P=0.006）.结论 宫颈癌的发生与HPV感染有关,也与血清STNFR Ⅰ与STNFRⅡ水平有相关性.

Objective To explore the relationship between cervical cancer and human papilloma virus（HPV） infection as well as soluble tumor necrosis factor receptors （STNFR）.Methods A total of 53 patients with cervical cancer were enrolled in the case group,while 50 healthy subjects were included in the control group.Clinical data,HPV and STNFR testing results of two groups were collected,analyzed and compared.Results 62.26% and 16.00% subjects in case group and control group respectively got infected with HPV.There was significant difference between the infection rate（P 〈 0.01）.The level of STNFR Ⅰ and STNFR Ⅱ were 1842.65 ± 1124.35pg· ml^-1 and 3248.60 ± 1048.65pg· ml^-1 respectively in case group,which were significantly higher than that of control group （849.32 ± 228.74pg· ml^-1 and 1653.27 ± 358.42pg· ml^-1） （STNFRⅠ： P =0.043,STNFR Ⅱ： P =0.047）.In the case group,the level of STNFR Ⅰ （2210.52 ± 1213.71pg· ml^-1） and STNFR Ⅱ （3679.24 ± 1088.15pg· ml^-1） in subjects with HPV infection were significantly higher than that of patients without HPV infection （STNFR Ⅰ： 1149.34 ± 603.14 pg· ml^-1,STNFR Ⅱ2667.23 ± 819.87pg· ml^-1） before surgery.However,after surgery,there were no statistically differences between the level of STNFR Ⅰ and STNFRⅡamong patients with or without HPV infection.In case group,the level of STNFR Ⅰ（1080.31 ±249.67pg· ml^-1） and STNFRⅡ（1896.32 ±211.75pg· ml^-1） after surgery were statistically lower than that before surgery（STNFR Ⅰ： 1822.36 ± 1128.16pg· ml^-1,STNFR Ⅱ： 3293.14 ± 1021.58pg· ml^-1） （STNFRⅠ： P =0.039,STNFRⅡ： P =0.006）.Conclusions Cervical cancer were associated HPV infection and the level of STNFR Ⅰ and STNFRⅡ.