产后抑郁症患者听感觉门控P50的研究

Research on the P50 Auditory Sensory Gating Potential in Patients with Postpartum Depression

目的:探讨产后抑郁症患者感觉门控P50的变化特征,为产后抑郁患者的早期预防提供参考依据。方法:采用配对听觉条件(S1)、测试(S2)刺激范式,对本院2011年1月至2012年6月收治的26例产后抑郁症患者(实验组)进行听觉诱发电位P50检测,测量P50的潜伏期、波幅,并与25例健康被试者(对照组)的结果进行比较。结果:(1)与对照组相比,实验组S1-P50潜伏期[(56.62±17.42)ms vs.(49.86±15.21)ms],S2-P50潜伏期[(57.36±15.42)ms vs.(50.04±16.27)ms]的差异均无统计学意义(P>0.05);(2)与对照组相比,实验组S1-P50波幅[(3.58±1.72)μV vs.(1.13±0.91)μV]显著降低,差异有统计学意义(P<0.05);S2-P50波幅[(1.32±1.16)μV vs.(1.48±1.05)μV]差异无统计学意义(P>0.05);(3)与对照组相比,实验组S2/S1波幅比值[(1.17±0.26)vs.(0.41±0.13)]显著升高,差异有统计学意义(P<0.05)。结论:产后抑郁症患者感觉门控抑制能力有缺陷,P50受损指标可能为评估产后抑郁症患者的潜在生物学指标。

Objective： To explore the change characteristics of P50 auditory sensory gating potential in patients with postpartum depression and provide references for the prevention of postpartum depression in early phase. Methods： 26 cases of postpartum depression and 25 cases of healthy subjects were selected, the incubation period and amplitude of P50 was measured by paired clicks auditory condition/testing stimulating paradigm. Results： （1） There was no significant difference for S1-P50 latencies [（56.62 ± 17.42） ms vs. （49.86 ± 15.21） ms] and $2-P50 latencies [（57.36 ±15.42） ms vs. （50.04 ±16.27） ms] between the experimental group and the control group （p〉0.05）. （2） Compared with the control group, the amplitude of S1-P50 was significantly lower [（3.58 ±1.72） μV vs. （1.13 ±0.91） μV, P〈0.05], and no significant difference of the amplitude of S2-P50 was [（1.32 ± 1.16） μV vs. （1.48 ± 1.05） IxV, P 〉0.05] found between two groups. （3） Compared with the control group, the amplitude ratio of S2/S 1 was significantly higher [（1.17 ± 0.26） vs. （0.41 ± 0.13）, P〈0.05] in the experimental group. Conclusion： Postpartum depression presented defect on the inhibiting ability of auditory sen- sory gating potential in a certain extent. P50 damaged indicator may be a potential biological marker for the evaluation of postpartum depression.