二琉基丁二酸治疗儿童铅中毒50例

DMSA for treatment of lead poisoning in children

目的探讨二琉基丁二酸(DMSA)联合营养素对儿童铅中毒的治疗效果。方法血铅>100μg/L患儿100例,随机分为观察组与对照组各50例,观察组采用DMSA与营养素联合治疗,对照组单独采用营养素治疗,同时对2组患儿家长进行有关铅中毒的防护、治疗方法等宣教,对比2组患儿治疗4、12周后的临床疗效。结果治疗4周后,2组患儿血铅水平均明显下降,与治疗前比较差异有统计学意义(P<0.05),观察组血铅下降幅度高于对照组(P<0.05),治疗12周后,观察组血铅水平继续下降,对照组血铅水平无明显变化,组间比较差异有统计学意义(P<0.05)。结论 DMSA联合营养素治疗儿童铅中毒能明显降低血铅水平,无明显不良反应。

Objective To investigate the therapeutic effect of DMSA combined with nutrients on children lead poisoning. Methods 100 cases with blood lead 〉 100 （including g/L） were randomly divided into observation group and control group. There were 50 cases in each group. The observation group was given dimercaptosuccinic acid （DMSA） and nutrients. The control group was only given nutrients. At the same time, the protection knowledge and therapeutic method of lead poi- soning were introduced to the parents. The clinical curative effects of two groups were compared after the treatment in week 4 and 12. Results After 4 weeks of treatment, blood lead levels of children in two groups were significantly decreased （ P 〈 0.05）,and the blood lead decrease of observation group is higher than that of the control group （P 〈 0.05）. After 12 weeks of treatment,blood lead levels in the observation group continue to decline, and blood lead level in the control group has no obvious change. The difference between groups is significant （ P 〈 0.05）. Conclusion DMSA combined with nutri- ents has obvious therapeutic effect on lead poisoning in children without obvious adverse reaction.