美沙酮低剂量维持治疗相关因素的分析

The analysis of the relevant factors during methadone low-dose maintenance therapy

目的:了解海洛因依赖者在美沙酮维持治疗过程中,实现低剂量(<30mg/日)维持的相关因素。方法:分析低剂量维持组受治者入组情况、治疗经过及实施心理行为干预措施的效果,并与非低剂量受治者对照。结果:低剂量美沙酮维持治疗,与开始治疗时受治者滥用海洛因的时间、用量、曾经戒断次数关系密切,治疗过程中心理行为干预措施较规范,服药缺失和尿检阳性率较低。结论:尽早开始美沙酮维持治疗、规范的心理行为干预措施有助于实现低剂量维持,达到足量防复吸与低量保维持的良好效果。

Objective： To understand the relevant factors during methadone maintenance treatment （Methadone Maintenance Treat- ment, MMT） process in low dose （ 〈 30rag/day）. Methods： The situation of low-dose group enrolled in, the process of MMT and the effect of psychological and behavioral interventions were analyzed, compared with the non-low-dose. Results： The group of low-dose methadone maintenance therapy is closely related to the dosage of heroin, numbers of once withdrawal, the psychological and behavioral interventions in the treatment process, lack of medication and urine tests positive. Conclusion： The early start of methadone mainte- nance treatment, standardized psychological and behavioral interventions contribute to the achievement of low-dose maintenance. Enough dose for relapse prevention and the lower amount for security are important for the best results.