辛伐他汀联合棓丙酯对高脂血症的疗效观察

Therapeutic effect of simvastatin combined with propylgallat on hyperlipemia

目的观察辛伐他汀联合棓丙酯治疗高脂血症的疗效及安全性。方法选取来我院就诊的不稳定心绞痛伴高脂血症患者116例,并随机分为对照组56例和治疗组60例。对照组给予辛伐他汀等常规治疗,治疗组在辛伐他汀治疗基础上给予棓丙酯注射液120 ml,静脉滴注,1次/d,疗程14 d。所有患者在清晨空腹抽取血样,测定血脂和血流变值。结果两组患者的血总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)都较治疗前降低,高密度脂蛋白胆固醇(HDL-C)水平较治疗前升高,差异有统计学意义(P<0.05);两组治疗后的血脂指标TC、TG及LDL-C比较均具有统计学差异(P<0.05),血流变指标比较也具有统计学差异(P<0.05)。结论辛伐他汀联合棓丙酯对高脂血症的降脂疗效优于单独使用辛伐他汀治疗。

Objective To inspect the therapeutic effect of simvastatin combined with propylgallat on hyperlipemia and its safety. Methods A total of 116 patients with unstable angina pectofis complicated with hyperlipemia were divided into trial group （ n = 60） and control group （n = 56 ） at random. The control group was treated only with simvastatin for unstable angina and the trial group was treated with injection of propylgallat （ 120 ml via intravenous infusion once a day） in addition for fourteen days as a course. Fasting lipid levels and hemorheological parameters were detected in all the patients early in the morning. Results The blood levels of TC, TG and LDL-C decreased and HDL-C increased significantly in both the two groups after therapy （P 〈 0.05 ）. After treatment, the differences in the levels of TC, TG and LDL-C were statistically significant between the two groups （ P 〈 0.05 ） and so were the improvements in hemorheology parameters （ P 〈 0.05 ）. Conclusion Simvastatin combined with propylgallat is more effective on hyperlipemia than single simvastatin.