病毒感染所致的喘息性支气管炎患儿血清嗜酸性粒细胞趋化因子的检测及临床意义

Detection and clinical significance of eotaxin in serum of children with virus infection caused by asthmatic bronchitis.

目的探讨血清嗜酸性粒细胞趋化因子(Eotaxin)在病毒感染喘息性支气管炎发病中的作用。方法采用酶联免疫吸附试验方法测定60例病毒感染喘息性支气管炎急性期和40例恢复期患儿以及40例健康儿童血清Eotaxin水平,比较三组儿童的血清Eotaxin水平,分析病毒感染喘息性支气管炎喘息反复发作的可能相关因素。结果急性期血清Eotaxin水平高于恢复期和对照组,差异均具有统计学意义(P<0.05);恢复期血清Eotaxin水平与对照组相比差异无统计学意义(P>0.05)。随访期内有20例患儿喘息反复发作,其血清Eotaxin水平为(139.45±41.63)pg/ml。有特应质性疾病史、家族遗传史和体重肥胖患儿血清Eotaxin水平显著高于无特应质性疾病史、家族遗传史和体重正常患儿,组间比较其差异均具有统计学意义(P<0.05)。结论血清Eotaxin在病毒感染喘息性支气管炎的发生和发展中起着一定的作用,参与了喘息复发和其他病毒感染所致的喘息性支气管炎患儿易喘息的反复发作。

Objective To investigate the effect of serum eotaxin in children with virus infection caused by asthmatic bronchitis, and analyze the relationship between serum eotaxin level and breathing-related risk factors. Methods Sixty children with virus infection caused by asthmatic bronchitis during the acute period and 40 children during the recovery period, and 40 healthy children were used as objects of study. The serum eotaxin level was tested by ELISA. The breathing-related risk factors of breathing repeated attack in children with virus infection caused by asthmatic bronchitis were screened. Results The serum eotaxin level of acute period was higher than that of the recovery period and the control group, with significant difference （P〈0.05）; the serum eotaxin level showed no significant difference between the recovery period and the control group. There were 20 children with breathing repeated attack in the follow-up period, the serum eotaxin level was （139.45±41.63） pg/ml. The serum Eotaxin level of children with atopic qualitative medical history, family genetic history and weight obesity were significantly higher than that without history of atopie qualitative disease and amily genetic and normal weight, with significant difference （P〈0.05）;. Conclusion The serum eotaxin is involved in the occurrence and development of virus infection caused by asthmatic bronchitis and breathing repeated attack. The children with virus infection caused by asthmatic bronchitis complicated by history of atopic qualitative disease and amily genetic and weight obesity are prone to breathing repeated attack.