幽门螺杆菌感染与ABO血型及胃肠激素的相关性

Correlation of Helicobacter pylori infection with ABO blood group and gastrointestinal hormone

目的探讨幽门螺杆菌(H.pylori)感染性消化性溃疡(peptic ulcer,PU)与ABO血型及胃肠激素的相关关系。方法随机选择217例消化性溃疡患者为研究组(PU组)和236例健康志愿者为对照组,分别采用放射免疫法和微柱凝胶法检测胃泌素、生长抑素水平和ABO血型,比较ABO血型胃泌素、生长抑素水平和H.pylori感染的差异。结果PU组O型血者占48.85%,明显高于O型血在正常人群中的分布(32.20%,P<0.05);无论是消化性溃疡患者还是健康者,O型血人群的H.pylori感染率均显著高于非O血型(P<0.05-0.01);O型对照组胃泌素水平比非O型各组高,但无显著性差异(P>0.05);对照各组生长抑素水平无差异(P>0.05);而PU组O型胃泌素水平升高,与各对照组相比有显著性差异(P<0.05);PU组O型生长抑素水平则下降,与其他各组相比有显著性差异(P<0.05)。结论 ABO血型中O型血者易患消化性溃疡,幽门螺杆菌的易感性及胃肠激素分泌紊乱是关键因素.

Objective To explore the relationship of helicobacter pylori（H.pylori） infectious peptic ulcer（PU） with ABO blood group and gastrointestinal hormones. Methods RIA method was used to detect the gastrin and the level of somatostatin and ABO blood type by the micro column gel method. And the difference in gastric secrete element of ABO blood group,somatostatin level and H.pylori infection were compared among 217 patients with peptic ulcer as the experiment group（PU）and 236 healthy volunteers as control group. Results The peptic ulcer patients had a significantly higher rate of blood group O than the control group（48.85% vs 32.20%, P 0.05）; Both peptic ulcer patient and healthy subject with blood group O had a significantly higher infection rate of H.pylori compared to patients with non-blood group O（P 0.05~ 0.01）;The gastrin level in patients of group with blood group O were higher than that in non O groups without significant difference（P 0.05）; difference among control groups of somatostatin level showed no statistically significant（P 0.05）; but secrete hormone levels of gastrin in patients with blood group O in PU group were demonstrated（P 0.05）as compared with the control group; somatostatin level of type O in PU group declined, having significant difference as compared with other groups（P 0.05）. Conclusion The patients with blood group O could suffer from peptic ulcer, mainly due to susceptibility of patiens to helicobacter pylori and disorder of gastric hormone secretion.