急性髓系白血病患者化疗后引起医院感染的相关因素分析

Risk factors associated with nosocomial infection in patients with acute myelogenous leukemia after chemotherapy

目的分析急性髓系白血病(AML)患者化疗后住院期间引起感染的相关因素,并探讨其预防措施。方法 166例AML患者接受化疗554例次,回顾性分析所有患者的病历资料,对其年龄、中性粒细胞绝对值、粒细胞缺乏持续时间与医院感染发生率的关系进行分析。结果年龄>60岁者医院感染发生率明显高于年龄<60岁者(75.6%vs.32.9%,P<0.05)。ANC最低值<0.5×109/L者医院感染发生率明显高于ANC最低值>0.5×109/L者(89.0%vs.53.0%,P<0.05)。粒细胞缺乏持续时间>7d者医院感染发生率明显高于粒细胞缺乏持续时间≤7d者(95.7%vs.79.2%,P<0.05)。结论年龄、中性粒细胞缺乏及持续时间是导致AML患者化疗后医院感染的危险因素,针对这些危险因素采取有效预防措施对降低AML患者化疗后医院感染率十分必要。

Objective To explore the risk factors associated with nosocomial infection in patients with acute myelogenous leukemia after chemotherapy. Methods The 166 patients with acute myelogenous leukemia received 554 times of chemotherapy. A retrospective analysis of the medical records of all patients was used to analyze the relationship between nosocomial infection and age, absolute neutrophil count in peripheral blood, the duration of agranulocytosis. Results The incidence of nosocomial infection in over 60-year old patients was significantly higher than that 60-years patients（75.6% vs.32.9%, P0.05）. The incidence of nosocomial infection in patients with nadir ANC 0.5 × 109/L was significantly higher than the nadir ANC 0.5 × 109/L（89.0% vs. 53.0%, P 0.05）. The incidence of nosocomial infection in patients with duration of neutropenia7d was significantly higher than the patients with duration of neutropenia ≤7d（95.7% vs. 79.2%, P0.05）.Conclusion Age, the neutrocytopenia level and prolongation are related to the nosocomial infection in patients with acute myelogenous leukemia. It is necessary to take positive measures to control nosocomial infection and enhance life quality of patients.