阿奇霉素序贯法治疗小儿肺炎支原体肺炎的效果及安全性

The Effectiveness and Safety of Mycoplasma Pneumoniae Pneumonia with Azithromycin Sequential Therapy

目的:评价阿奇霉素序贯法治疗小儿肺炎支原体肺炎的有效性及安全性。方法:选取2011-2013年笔者所在医院收治的80例小儿肺炎支原体肺炎患儿,随机分为两组,其中观察组40例采用阿奇霉素序贯法治疗,对照组40例采用红霉素序贯法治疗,观察并比较两组的临床疗效及不良反应发生情况。结果:观察组总有效率为95.0%,对照组为85.0%,差异有统计学意义(P<0.05);观察组患儿的皮疹、肝功能异常、局部疼痛、转氨酶升高及胃肠道反应等药物不良反应发生率均低于对照组,差异有统计学意义(P<0.05)。结论:阿奇霉素序贯法治疗小儿肺炎支原体肺炎疗效好,安全性高,值得在临床上予以推广。

Objective：To evaluate the efficacy and safety of Mycoplasma pneumoniae pneumonia with azithromycin sequential therapy. Method：80 cases of Mycoplasma pneumoniae pneumonia from Jan 2011 to Dec 2013 admitted to our hospital were randomly divided into observation group（n=40） and control group（n=40）,observation group was given azithromycin sequential therapy,control group was given erythromycin sequential therapy,observed and compared the efficacy and adverse events of two groups.Result：The total effective rate of observation group was 95.0%,control group was 85.0%,the difference was statistically significant（P〈0.05）;The rash,abnormal liver function,local pain,elevated transaminases and gastrointestinal road reactions adverse drug reactions of observation group were lower than control group,the differences were statistically significant（P〈0.05）.Conclusion：Mycoplasma pneumoniae pneumonia with azithromycin sequential therapy is effective,safe,to be worthy of promotion in clinical practice.