维拉帕米快速转复阵发性室上性心动过速的临床分析

A Clinical Analysis of Fast Conversion of Paroxysmal Supraventricular Tachycardia by Vera Pamil

目的：观察维拉帕米快速转复阵发性室上性心动过速的治疗效果与不良反应。方法：分析笔者所在医院2010年1月-2013年6月静注维拉帕米治疗阵发性室上性心动过速共103例患者的临床资料，首剂静脉负荷剂量5 mg加入5%葡萄糖溶液或生理盐水20 ml中5－10 min内静注，静注过程中，室上性心动过速终止转为窦律后立即停止用药，无效者在20 min后重复静注1次。结果：103例患者中，成功恢复窦性心律96例，成功率93.2%，出现不良反应8例，不良反应率为7.8%。结论：维拉帕米对阵发性室上性心动过速转复成功率高，不良反应少，是急诊治疗阵发性室上性心动过速的一线药物，正确的使用方法可提高疗效。

Objective：To observe the treatment effect and adverse reactions of fast conversion of paroxysmal supraventricular tachycardia by Verapamil. Method：Clinical data of patients with paroxysmal supraventricular tachycardia treated with at least once intravenous injection of Verapamil in our hospital from January 2010 to June 2013（n=103） were analyzed.The first loading dose was 5 mg Verapamil in 20 ml of 5%glucose or physiological saline solution,and it was intravenously injected within 5 to 10 min,which was suspended immediately if supraventricular tachycardia was switched to sinus rhythm during the injection,and a repeated injection was did after 20 min if the first dose was ineffective.Result：There were 96 cases in 103 cases successfully restored their sinus rhythms,and the success rate was 93.2%,and 8 cases（7.8%） showed adverse reactions.Conclusion：Verapamil is effective to treat paroxysmal supraventricular tachycardia with a high cardioversion rate and fewer adverse reaction.Therefore,it should be the first-line drug in the treatment of paroxysmal supraventricular tachycardia in the emergency room,and a correct use method may further improve its effect.