血清尿酸、总胆红素水平与冠状动脉粥样斑块进展的相关性分析

Correlation between serum uric acid and total bilirubin levels and coronary atherosclerotic plaques

目的探讨血清尿酸(uric acid,UA)、总胆红素(total bilirubin,TBIL)水平与冠状动脉粥样斑块进展的关系。方法从2009年1月1日-2012年11月1日期间在解放军总医院心血管内科行两次冠状动脉造影的冠状动脉粥样硬化性心脏病患者中随机选取300例,根据定量冠状动脉造影分析结果分为斑块进展组(183例)和斑块非进展组(109例)。结果两组患者在血清UA[(337.02±45.26)μmol/L vs(291.47±53.65)μmol/L,P=0.025)]和TBIL[(10.96±1.73)μmol/L vs(13.08±1.94)μmol/L,P=0.03)]水平差异均有统计学意义。结论血清UA水平的升高、TBIL水平的降低与冠心病的发生及其严重程度有关,借助这些指标的变化对冠心病的早期预防、诊治及预后评估具有一定价值。

Objective To study the correlation between serum uric acid （UA） and total bilirubin（TBIL） levels and coronary atherosclerotic plaques. Methods Two hundred and ninety-two patients se lected from 300 patients with atherosclerotic coronary heart disease （CHD） who underwent twice of coronary angiography in our hospital from January 2009 to November 2012 were divided into progressive atherosclerotic plaque group （n=183） and non-progressive atherosclerotic plaque group （n=109） according to their quantitative coronary angiography （QCA）. Correlation between their serum UA and TBIL levels and their coronary atherosclerotic plaques was analyzed. Results The serum UA and TBIL levels were significantly higher in progressive atherosclerotic plaque group than in non-progressive atherosclerotic plaque group （337.02±45.26 vs 291.47±53.6, P=0.025;13.08±1.94 vs 10.96±1.73, P=0.03）. Conclusion Higher serum UA level and lower serum TBIL level are correlated with the occurrence and severity of CHD, and can thus be used as a predictor for its early prevention, diagnosis and prognosis.