慢性疲劳综合征患者和健康人睡眠主客观评价对比分析

Comparative Analysis of Objective and Subjective Sleep Evaluation in CFS Patients and Healthy People

目的:探讨慢性疲劳综合征(CFS)患者和健康人主客观评价的差异,分析慢性疲劳综合征患者睡眠障碍的特点。方法:招募72例慢性疲劳综合征患者和72例年龄、性别、体重指数相匹配的健康受试者。所有受试者均接受整夜多导睡眠监测,以及清晨问卷和匹兹堡睡眠质量指数量表评价。结果:①客观评价方面,CFS患者和健康受试者总卧床时间、睡眠潜伏期、总睡眠时间、睡眠效率、N1百分比、N2百分比、N3百分比、REM睡眠期百分比差异均无统计学意义(P>0.05)。但CFS患者觉醒次数、觉醒时间有高于健康受试者的趋势,NREM睡眠3期百分比有低于健康受试者的趋势。②主观评价方面,CFS患者和健康受试者睡眠潜伏期、总睡眠时间、觉醒次数、觉醒时间比较差异具有统计学意义(P<0.05)。两组受试者PSQI量表各项目评分及总分差异具有统计学意义(P<0.05)。结论:CFS患者客观睡眠结构没有特征性的改变,NREM睡眠3期百分比有低于健康受试者的趋势;主观睡眠质量较健康受试者差。

Objective ： To explore the characteristics of objective and subjective sleep evaluations. Methods ： A total of 72 CFS patients and 72 healthy individuals were recruited in. Polysomnogram parameters were employed to evaluate the objective sleep measures, questionnaire and PSQI scores to evaluate subjective sleep. Results：①In objective sleep aspect, group CFS patients and healthy individuals group had no statistical difference in total sleep time, sleep latent, awakening number, awakening time and sleep efficiency （ P 〉 0. 05 ）. But CFS patients had a trend of increasing awakening number and awakening time. ②In Subjective sleep aspect, the following outcomes in group CFS patients and healthy individuals were statistically different：total sleep time, sleep latent, awakening number, awakening time of morning questionnaire （ P 〈 0. 05 ）. Group CFS patients were statistically different from healthy individuals in PSQI scores and suhseales （ P 〈0. 05 ）. Conclusion ： The objective sleep architecture has no characteristic change. Compared with healthy individuals, CFS patients have prolonged sleep latent, awakening number, awakening time and reduced total sleep time of morning questionnaire. CFS patients have poor sleep quality and daytime dysfunction.