IL-2联合α-干扰素与单药顺铂治疗恶性胸腔积液的比较研究

Comparative study of IL-2 combined with α-INF and single agent cisplatin in the treatment of malignant pleural effusion

目的比较两种方案局部治疗恶性胸腔积液的近期疗效和安全性。方法 86例恶性胸腔积液患者随机分为两组,即观察组44例,对照组42例。胸腔置管排净胸腔积液后,观察组胸腔注射白介素-2（IL-2）联合α-干扰素（α-INF）,对照组胸腔内注射单药顺铂,均为每周1次,每次40 mg,共1~3次。4周后观察两组患者近期疗效及安全性。结果 86例患者均可评价近期疗效及毒副反应。观察组和对照组的有效率分别为61.4%和57.1%（P〉0.05）。观察组毒性反应以发热、胸痛为主,对照组以白细胞下降及消化道反应为主。观察组的发热稍高于对照组（P〉0.05）,而对照组的白细胞下降及消化道反应明显高于观察组（P〈0.05）。结论 IL-2联合α-INF是治疗恶性胸腔积液的一种有效、安全性好的方法之一,值得临床进一步研究应用。

Objective To compare the efficacy and safety of two schemes for local treatment of malignant pleural effusion. Methods Eighty-six cases of patients with malignant pleural effusion were randomly divided into two groups,the observation group 44 cases,control group 42. After chest tube drainage of pleural effusion,the observation group was injected by interleukin-2（ IL-2） plus interferon-α（ α-INF）,control group were injected by single drug cisplatin,once per week,40 mg per time,totally 1 ~3 times. Two groups were observed in short-term efficacy and safety after 4 weeks. Results Response rate and toxicity could be evaluated in all the patients. In observation group and control group,the response rates were 61. 4% and 57. 1%（ P ＆gt; 0. 05）. The main toxicities were fever and chest pain in the observation group,the control group with the decrease of white blood cells and digestive tract reaction. There were more decrease of white blood cells and digestive tract reaction in the control group（ P ＆lt; 0. 05）,and more fever in the observation group（ P ＆gt; 0. 05）. Conclusions IL-2 combined with α-INF is one of an effective and safe treatment of malignant pleural effusion,which is worthy of further clinical application.