转化生长因子-β1在乙型肝炎病毒感染相关肝病发病中的作用研究进展

Pathogenesis effects of transforming growth factor-β1 in hepatitis B virus infection-related liver diseases

转化生长因子-β1(TGF-β1)是一种具有广泛生物学功能的细胞因子。TGF-β1可能参与了介导免疫细胞数量和功能的异常而诱导免疫耐受,使乙型肝炎病毒(HBV)感染慢性化,但同时可能通过多种途径参与抑制HBV复制;TGF-β1促进肝纤维化发生,对肝癌发生起双向调节作用,同时参与肝衰竭的发生。

Transforming growth factor-β1（TGF-β1） is a kind of cytokine with broad biological functions. It induces ab-normality in cell number and function of immune cells and results in chronic infection of hepatitis B virus （HBV）;At the same time,TGF-β1 inhibits HBV replication through different ways;TGF-β1 also promotes liver fibrosis,affects hepatocellular carcino-ma in a dual manner,and plays a significant role in the development of liver failure.