代谢综合征相关指标与血清总前列腺特异性抗原相关性分析

Correlation analysis of metabolic syndrome-related indicators and serum prostate-specific antigen levels

目的探讨代谢综合征(MS)相关指标肌酐(Cr)、尿素(UREA)、总胆固醇(TC)、三酰甘油(TG)、空腹血糖(FBG)与血清总前列腺特异性抗原(T-PSA)的相关性。方法选择2012年11月至2013年4月在南京医科大学第一附属医院健康体检的男性386例,分别测量其身高、体质量并计算体质量指数(BMI),检测TC、TG、FBG、Cr、UREA及T-PSA的水平并进行统计学分析。结果血清T-PSA、FBG、Cr水平随年龄的增加而升高,差异有统计学意义(F=17.65,F=3.46,F=19.55,P<0.05),BMI指数随年龄的增加呈降低趋势,差异有统计学意义(F=23.45,P<0.05),血清TC水平随年龄的增加有升高趋势,差异无统计学意义(F=2.24,P>0.05),血清TG、UREA水平各组间比较差异无统计学意义(F=2.13,F=2.68,P>0.05)。血清T-PSA与血清TC、FBG、Cr、UREA、年龄呈正相关(P<0.05);与BMI呈负相关(P<0.05);与血清TG无明显相关性(P>0.05)。结论 T-PSA水平与年龄、体质量、Cr、UREA、TC、FBG存在相关性,MS相关指标是其升高的相关危险因素。

Objective To investigated the relationship between related indicators of metabolic syndrome（MS）, serum creatinine （Cr）, urea（UREA）, total cholesterol（TC）, triglycerides（TG） and fasting blood glucose （FBG）and serum total prostate specific an-tigen（T-PSA） levels. Methods A total of 386 elderly men who had routine visit in medical center of the first affiliated hospital of nanjing medical university from November 2012 to April 2013 were recruited for this study. Height,weight were measured and body mass index （BMI）was calculated. Serum TC, TG, FBG, Cr and UREA, and T-PSA were measured. T-test was used to compare groups. Correlation analysis was performed using pearson correlation analysis. Results With the advance of age,the levels of T- PSA, FBG,Cr had an increasing trend, with significant difference among groups（F=17.65, F= 3.46, F=19.55, P〈0.05）, BMI had an decreasing trend, with significant difference among groups（F= 23.45, P〈0.05）. With the advance of age, the levels of TC had an increasing trend, with no statistically significant difference among groups （F = 2. 24, P 〉 0.05）. There were no significant difference in TG, UREA between the groups （F=2.13, F = 2.68, P〉 0.05）. TC, FBG, Cr, UREA, age with T-PSA positively corre-lated（P〈0.05） ,BMI with T-PSA negative correlation（P〈0.05）. And there was no obvious correlation of serum TG（P〉0.05）. Conclusion Levels of serum prostate-specific antigen and age,body weight, creatinine, urea, total cholesterol, fasting plasma glucose correlated,metabolic syndrome-related indicators is the risk factors for exaltation of serum T-PSA.