母牛分枝杆菌菌苗对无症状期HIV感染者CD4^+和CD8^+T细胞计数及病毒载量的影响

Impact of Mycobacterium vaccae vaccine on CD4^+ T cell and CD8^+ T cell counts and viral load in asymptomatic HIV-infected patients

目的探讨母牛分枝杆菌菌苗对无症状期HIV感染者CD4+和CD8+T细胞计数及病毒载量的影响。方法以无症状期HIV感染者为研究对象,随机分为治疗组Ⅰ、Ⅱ和对照组Ⅰ、Ⅱ,治疗组予肌肉注射母牛分枝杆菌菌苗,比较分析4组患者治疗2个月后CD4+和CD8+T细胞计数及病毒载量的变化。结果治疗组Ⅰ、Ⅱ的CD4+、CD4+/CD8+治疗后明显高于治疗前和对照组Ⅰ、Ⅱ,差异有统计学意义(P<0.05),但病毒载量无明显变化,差异无统计学意义(P>0.05),而对照组的CD4+、CD4+/CD8+细胞计数及病毒载量治疗前后比较差异无统计学意义(P>0.05)。结论母牛分枝杆菌菌苗对无症状期HIV感染者能增强细胞免疫功能但对HIV病毒载量无明显影响。

Objective To investigate the impact of Mycobacteriurn vaccae vaccine on CD4^＋ T cell and CD8^＋ T cell counts and viral load in asymptomatic HIV-infected patients. Methods The asymptomatic HIV-infected patients as the research subjects were randomly divided into the treatment group Ⅰ , Ⅱ and the control group Ⅰ , Ⅱ The treatment groups were intramuscularly injected by Mycobacterium vaccae vaccine. The CD4^＋ T cell and CD8^＋ T cell counts and viral load after 2 months of treatment were per-formed the comparative analysis among the four groups. Resul!s The CD4＋ T cell counts and the ratio of CD4^＋/CD8^＋ in the treat-ment group Ⅰ and Ⅱ were significantly higher than those before treatment and the control group Ⅰ and Ⅱ ,the differences had sta-tistical significance（P〈0.05） ,but the viral load had no significant change without statistical difference（P〉0.05） ,while the CD4^＋ T cell count and the ratio of CD4^＋/CD8^＋ and viral load in the control groups had no statistical differences between before and after treatment （P〉0.05）. Conclusion Mycobacteriurn vaccae vaccine can enhance the cellular immune function on asymptomatic HIV-infected patients,but without significant influence on the HIV viral load.