载脂蛋白E在心血管疾病中的诊断价值

Apolipoprotein E and cardiovascular disease related research

目的对冠心病(CHD)组、心肌梗死(MI)组及对照组进行血脂等相关项目测定,运用统计学方法探讨载脂蛋白E(ApoE)与CHD及MI的内在联系。方法应用Olympus AU5400全自动生化分析仪测定各组标本的血脂相关项目指标如三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、ApoE及ApoE对CHD、MI的相关分析。结果 CHD组ApoE、TG、LDL-C、ApoB较对照组明显升高,ApoA1、HDL-C较对照组明显降低,差异有统计学意义(P<0.05)。MI组ApoE、TG、ApoB较对照组高,MI组HDL-C、ApoA1较对照组降低,差异有统计学意义(P<0.05)。MI组中ApoE与血脂相关项目的相关性高于CHD组。结论 ApoE与心血管疾病具有明显相关性,其测定结果升高可以作为MI的辅助诊断指标。

Objective To measure the indexes of relevant items of blood lipid from the coronary heart disease （CHD）group,the myocardial infarction （MI） group as well as the normal control group, and applying statistical methods to analyze and discuss the in-ternal relationship of apolipoprotein E （ApoE）with CHD and MI. Methods Used Olympus AU5400 automatic biochemistry analy-zer to determine each specimen of blood lipid related items , such as triglyceride （TCJ）, total cholesterol （TC） ,high-density lipopro-rein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, Apolipoprotein A1 （ApoAl）, apolipoprotein B （ApoB）, ApoE indexes,and ApoE correlation analysis on CHD,MI. Results ApoE,TG,LDL-C,ApoB in CHD group was higher than con- trol group obviously, ApoAl, HDL-C significantly lower than the control group, the difference was statistically significant （P〈 0.05）, ApoE,TG, ApoB of MI group was higher than control group, HDL-C, ApoAl in MI group reduced than the control group, the difference was statistically significant （P〈0.05）, The correlation of blood lipid related items and ApoE within the MI group was stronger than CHD group. Conclusion The increased ApoE result can probably be used as a myocardial infarction assistant di-agnosis index.