吸入型糖皮质激素对中重度哮喘患儿急性发作的影响

Effect of Inhaled Corticosteroids on Acute Attack of Children Asthma with Moderate to Severe

目的：对中重度哮喘患儿急性发作期使用吸入型糖皮质激素（ICS）治疗,以探讨其疗效和安全性。方法：将78例婴幼儿哮喘急性发作患者按照就诊顺序随机分为2组,对照组常规治疗,试验组加吸ICS,治疗（3-7）d后比较两组咳嗽、喘憋、肺部哮鸣音和湿啰音消失时间及疗效。结果：试验组咳嗽、喘憋、肺部哮鸣音和湿啰音消失时间分别为（4.9±2.1）、（5.2±1.3）、（6.8±2.6）、（7.5±3.3）,与对照组相比差异均有统计学意义（9.9±2.5）、（11.3±4.2）、（13.5±5.2）、（14.5±6.2）（P〈0.01）；试验组和对照组有效率分别为92.3%和82.1%,差异有统计学意义（Ridit z=9.845,P=0.000）。结论：ICS治疗对中重度哮喘患儿急性发展期疗效显著,使症状体征消失时间短,副作用小,可以在临床推广使用。

Objective：Moderate to severe acute exacerbation of asthma using ICS therapy to investigate the efficacy and safety. Methods：78 cases of patients with acute exacerbation of asthma in infants and young children in accordance with the order of treatment were randomly divided into two groups, the control group were with conventional treatment, the test group were received suction ICS, 3-7d after treatment,compared coughing, wheezing, lungs wheezing sounds and wet rales disappeared time and efficacy.Results：The experimental group of coughing, wheezing, lungs wheezing sounds and moist rales disappeared time was （4.9 ± 2.1）, （5.2 ± 1.3）, （6.8 ± 2.6）, （7.5 ± 3.3）, compared with the control group than the differences were statistically significant （9.9 ± 2.5）, （11.3 ± 4.2）, （13.5 ± 5.2）, （14.5 ± 6.2） （P〈0.01）;The experimental group and the control group were 92.3%and 82.1%, the difference was statistically significant （Ridit z=9.845, P=0.000）.Conclusion：ICS therapy in children with acute severe asthma development period has a significant effect, the symptoms and signs disappeared a short time, side effects, it can be used in clinical practice.